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Coq4 coenzyme Q4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366013, updated on 17-Aug-2024

Summary

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Official Symbol
Coq4provided by RGD
Official Full Name
coenzyme Q4provided by RGD
Primary source
RGD:1304638
See related
EnsemblRapid:ENSRNOG00000026691 AllianceGenome:RGD:1304638
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in ubiquinone biosynthetic process. Predicted to be extrinsic component of mitochondrial inner membrane. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 7. Orthologous to human COQ4 (coenzyme Q4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 73.1), Kidney (RPKM 61.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Coq4 in Genome Data Viewer
Location:
3p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33457834..33468387)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13060054..13070502)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8349386..8357719)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486066 Neighboring gene TruB pseudouridine synthase family member 2 Neighboring gene solute carrier family 27 member 4 Neighboring gene ubiquitin related modifier 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis. Nguyen TP, et al. Biochim Biophys Acta, 2014 Nov. PMID 25152161, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC116264

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquinone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extrinsic component of mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquinone biosynthesis complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
Names
coenzyme Q biosynthesis protein 4 homolog
coenzyme Q4 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031662.1 → NP_001026832.1  ubiquinone biosynthesis protein COQ4 homolog, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001026832.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099123
    UniProtKB/Swiss-Prot
    Q4FZU1
    Related
    ENSRNOP00000038869.4, ENSRNOT00000038602.7
    Conserved Domains (1) summary
    pfam05019
    Location:62 → 258
    Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    33457834..33468387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284260.1 → XP_063140330.1  ubiquinone biosynthesis protein COQ4 homolog, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHW2, A6JTS3

  2. XM_039105582.2 → XP_038961510.1  ubiquinone biosynthesis protein COQ4 homolog, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam05019
    Location:66 → 213
    Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4

RNA

  1. XR_010064672.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4FZU1.1 GenPept UniProtKB/Swiss-Prot:Q4FZU1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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