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Tfb1 Transcription factor B1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36598, updated on 2-Nov-2024

Summary

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Official Symbol
Tfb1provided by FlyBase
Official Full Name
Transcription factor B1provided by FlyBase
Primary source
FLYBASE:FBgn0033929
Locus tag
Dmel_CG8151
See related
AllianceGenome:FB:FBgn0033929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8151; Dmel\CG8151; Dmp62; l(2)06949; l(2)06950; p62; TFB1; TfBl
Summary
Involved in response to UV. Part of transcription factor TFIIH holo complex. Is expressed in alimentary canal; larval brain; organism; pericardial cell; and testis. Orthologous to human GTF2H1 (general transcription factor IIH subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Tfb1 in Genome Data Viewer
Location:
50F6-50F6; 2-70 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14363048..14365473)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10250553..10252978)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Activity-regulated cytoskeleton associated protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. BSD: a novel domain in transcription factors and synapse-associated proteins. Doerks T, et al. Trends Biochem Sci, 2002 Apr. PMID 11943536
  2. Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly. Castro J, et al. DNA Repair (Amst), 2002 May 30. PMID 12509240
  3. Seven-Up Is a Novel Regulator of Insulin Signaling. Musselman LP, et al. Genetics, 2018 Apr. PMID 29487137, Free PMC Article
  4. The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila. Villicaña C, et al. J Cell Sci, 2013 Jun 1. PMID 23549790
  5. A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer. Stettler K, et al. Dis Model Mech, 2015 Jan. PMID 25431422, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA polymerase II promoter clearance ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transcription open complex formation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of transcription factor TFIIH core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH core complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIH core complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIH holo complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
transcription factor B1
Names
CG8151-PA
CG8151-PB
CG8151-PC
CG8151-PD
TFB1 ortholog
TfBl
Tfb1-PA
Tfb1-PB
Tfb1-PC
Tfb1-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14363048..14365473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137113.4 → NP_610957.1  transcription factor B1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610957.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZH0, Q0E978, Q960E8
    UniProtKB/TrEMBL
    A0A0B4K726
    Related
    FBpp0086676
    Conserved Domains (3) summary
    smart00751
    Location:104 → 157
    BSD; domain in transcription factors and synapse-associated proteins
    cd13229
    Location:10 → 104
    PH_TFIIH; Transcription Factor II H (TFIIH) Pleckstrin homology (PH) domain
    pfam03909
    Location:181 → 234
    BSD; BSD domain

  2. NM_001259392.2 → NP_001246321.1  transcription factor B1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246321.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZH0, Q0E978, Q960E8
    UniProtKB/TrEMBL
    A0A0B4K726
    Conserved Domains (3) summary
    smart00751
    Location:104 → 157
    BSD; domain in transcription factors and synapse-associated proteins
    cd13229
    Location:10 → 104
    PH_TFIIH; Transcription Factor II H (TFIIH) Pleckstrin homology (PH) domain
    pfam03909
    Location:181 → 234
    BSD; BSD domain

  3. NM_166048.1 → NP_725382.1  transcription factor B1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725382.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZH0, Q0E978, Q960E8
    UniProtKB/TrEMBL
    A0A0B4K726
    Related
    FBpp0086678, FBtr0087550
    Conserved Domains (3) summary
    smart00751
    Location:104 → 157
    BSD; domain in transcription factors and synapse-associated proteins
    cd13229
    Location:10 → 104
    PH_TFIIH; Transcription Factor II H (TFIIH) Pleckstrin homology (PH) domain
    pfam03909
    Location:181 → 234
    BSD; BSD domain

  4. NM_166049.1 → NP_725383.1  transcription factor B1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725383.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZH0, Q0E978, Q960E8
    UniProtKB/TrEMBL
    A0A0B4K726
    Related
    FBpp0086677, FBtr0087549
    Conserved Domains (3) summary
    smart00751
    Location:104 → 157
    BSD; domain in transcription factors and synapse-associated proteins
    cd13229
    Location:10 → 104
    PH_TFIIH; Transcription Factor II H (TFIIH) Pleckstrin homology (PH) domain
    pfam03909
    Location:181 → 234
    BSD; BSD domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K726 A0A0B4K726
Q960E8.1 Q960E8

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