U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Aph1a aph-1 homolog A, gamma secretase subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 365872, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Aph1aprovided by RGD
Official Full Name
aph-1 homolog A, gamma secretase subunitprovided by RGD
Primary source
RGD:1311546
See related
EnsemblRapid:ENSRNOG00000023816 AllianceGenome:RGD:1311546
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311546
Summary
Predicted to enable endopeptidase activator activity; enzyme binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including Notch receptor processing; amyloid-beta formation; and proteolysis. Predicted to act upstream of or within metanephros development. Located in cytoplasmic vesicle; mitochondrion; and synaptic membrane. Is integral component of presynaptic membrane. Orthologous to human APH1A (aph-1 homolog A, gamma-secretase subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 218.8), Heart (RPKM 177.4) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186123023..186130886)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183437676..183443113)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198006247..198009837)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S21 Neighboring gene circadian associated repressor of transcription Neighboring gene similar to human chromosome 1 open reading frame 54 Neighboring gene carbonic anhydrase 14 Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. [Effect of βsheet blocking peptide H102 on APP metabolic enzymes in hippocampal brain of double transgenic AD mice]. Jiang F, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2017 Apr 8. PMID 29926633
  2. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria. Hansson CA, et al. J Biol Chem, 2004 Dec 3. PMID 15456764
  3. Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Cheng HT, et al. Development, 2003 Oct. PMID 12952904
  4. Synaptic and endosomal localization of active gamma-secretase in rat brain. Frykman S, et al. PLoS One, 2010 Jan 28. PMID 20126630, Free PMC Article
  5. Three-dimensional structure of human γ-secretase. Lu P, et al. Nature, 2014 Aug 14. PMID 25043039, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates
    Title: Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates.
  2. Nicastrin, presenilin 1, APH-1, and PEN-2 form an active gamma-secretase complex expressed in mitochondria.
    Title: Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Notch receptor processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Notch receptor processing ISO
Inferred from Sequence Orthology
more info
  
involved_in Notch receptor processing ISO
Inferred from Sequence Orthology
more info
  
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in amyloid precursor protein metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane protein intracellular domain proteolysis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metanephros development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
part_of gamma-secretase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-secretase complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
gamma-secretase subunit APH-1A
Names
APH1A gamma secretase subunit
anterior pharynx defective 1 homolog A
anterior pharynx defective 1a homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014255.1 → NP_001014277.1  gamma-secretase subunit APH-1A

    See identical proteins and their annotated locations for NP_001014277.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087081
    UniProtKB/TrEMBL
    F7EYZ3, Q5PQQ3
    Conserved Domains (1) summary
    pfam06105
    Location:3 → 233
    Aph-1; Aph-1 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    186123023..186130886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232977.5 → XP_006233039.1  gamma-secretase subunit APH-1A isoform X1

    See identical proteins and their annotated locations for XP_006233039.1

    UniProtKB/TrEMBL
    A6K331, F7EYZ3
    Related
    ENSRNOP00000099913.1, ENSRNOT00000168623.1
    Conserved Domains (1) summary
    pfam06105
    Location:3 → 233
    Aph-1; Aph-1 protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools