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Hormad1 HORMA domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365868, updated on 2-Nov-2024

Summary

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Official Symbol
Hormad1provided by RGD
Official Full Name
HORMA domain containing 1provided by RGD
Primary source
RGD:1564960
See related
EnsemblRapid:ENSRNOG00000021160 AllianceGenome:RGD:1564960
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564960
Summary
Predicted to be involved in several processes, including meiosis I cell cycle process; meiotic sister chromatid cohesion; and regulation of cell cycle process. Predicted to act upstream of or within homologous chromosome pairing at meiosis. Predicted to be located in cytoplasm and synaptonemal complex. Orthologous to human HORMAD1 (HORMA domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 123.9) See more
Orthologs
human mouse all
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Genomic context

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See Hormad1 in Genome Data Viewer
Location:
2q34
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185803572..185841449)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183115815..183152383)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (197681820..197720197)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ataxin-8-like Neighboring gene cathepsin S Neighboring gene transfer RNA leucine (anticodon AAG) 16 Neighboring gene golgi phosphoprotein 3-like Neighboring gene RNA, U6 small nuclear 857 Neighboring gene endosulfine alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel mammalian HORMA domain-containing protein, HORMAD1, preferentially associates with unsynapsed meiotic chromosomes. Fukuda T, et al. Exp Cell Res, 2010 Jan 15. PMID 19686734
  2. Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. Wojtasz L, et al. PLoS Genet, 2009 Oct. PMID 19851446, Free PMC Article
  3. Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms. Wojtasz L, et al. Genes Dev, 2012 May 1. PMID 22549958, Free PMC Article
  4. Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. Shin YH, et al. PLoS Genet, 2010 Nov 4. PMID 21079677, Free PMC Article
  5. HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes. Kogo H, et al. Genes Cells, 2012 Jun. PMID 22530760

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in blastocyst development ISO
Inferred from Sequence Orthology
more info
  
involved_in blastocyst development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic DNA double-strand break formation ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic DNA double-strand break formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within meiotic recombination checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic recombination checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic recombination checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in meiotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic sister chromatid cohesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in oogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in oogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of homologous chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of homologous chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptonemal complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptonemal complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synaptonemal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
HORMA domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108949.1 → NP_001102419.1  HORMA domain-containing protein 1

    See identical proteins and their annotated locations for NP_001102419.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474015
    UniProtKB/Swiss-Prot
    D3ZWE7, D3ZZR2
    UniProtKB/TrEMBL
    A0A8I5ZSL6
    Related
    ENSRNOP00000105827.1, ENSRNOT00000154721.1
    Conserved Domains (1) summary
    pfam02301
    Location:27 → 221
    HORMA; HORMA domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    185803572..185841449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102781.2 → XP_038958709.1  HORMA domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3ZWE7, D3ZZR2
    UniProtKB/TrEMBL
    A0A8I5ZSL6
    Conserved Domains (1) summary
    pfam02301
    Location:27 → 221
    HORMA; HORMA domain

  2. XM_063282273.1 → XP_063138343.1  HORMA domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3ZWE7, D3ZZR2

  3. XM_006232951.5 → XP_006233013.1  HORMA domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006233013.1

    UniProtKB/Swiss-Prot
    D3ZWE7, D3ZZR2
    UniProtKB/TrEMBL
    A0A8I5ZSL6
    Related
    ENSRNOP00000063863.1, ENSRNOT00000066821.3
    Conserved Domains (1) summary
    pfam02301
    Location:27 → 221
    HORMA; HORMA domain

  4. XM_039102783.2 → XP_038958711.1  HORMA domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    pfam02301
    Location:27 → 187
    HORMA; HORMA domain

  5. XM_039102782.2 → XP_038958710.1  HORMA domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    pfam02301
    Location:2 → 93
    HORMA; HORMA domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZWE7.1 GenPept UniProtKB/Swiss-Prot:D3ZWE7

Gene LinkOut

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