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Tbl1xr1 TBL1X/Y related 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365755, updated on 2-Nov-2024

Summary

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Official Symbol
Tbl1xr1provided by RGD
Official Full Name
TBL1X/Y related 1provided by RGD
Primary source
RGD:1560053
See related
EnsemblRapid:ENSRNOG00000011216 AllianceGenome:RGD:1560053
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560053
Summary
Predicted to enable several functions, including beta-catenin binding activity; histone binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of canonical Wnt signaling pathway; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including blastocyst hatching; fat pad development; and white fat cell differentiation. Predicted to be located in mitotic spindle and nucleus. Predicted to be part of histone deacetylase complex and transcription repressor complex. Human ortholog(s) of this gene implicated in Pierpont syndrome and autosomal dominant intellectual developmental disorder 41. Orthologous to human TBL1XR1 (TBL1X/Y related 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 235.4), Spleen (RPKM 191.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tbl1xr1 in Genome Data Viewer
Location:
2q24
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (106718811..106857989)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (104788950..104929055)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (107221913..107359229)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100786 Neighboring gene spindlin-1-like Neighboring gene ribosomal protein L36, pseudogene Neighboring gene zinc finger protein 296, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcriptional cofactor TBLR1 controls lipid mobilization in white adipose tissue. Rohm M, et al. Cell Metab, 2013 Apr 2. PMID 23499424
  2. TBLR1 regulates the expression of nuclear hormone receptor co-repressors. Zhang XM, et al. BMC Cell Biol, 2006 Aug 7. PMID 16893456, Free PMC Article
  3. TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis. Li J, et al. Nat Cell Biol, 2008 Feb. PMID 18193033
  4. Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment. Ishii S, et al. Proc Natl Acad Sci U S A, 2008 Mar 18. PMID 18326024, Free PMC Article
  5. Reading and function of a histone code involved in targeting corepressor complexes for repression. Yoon HG, et al. Mol Cell Biol, 2005 Jan. PMID 15601853, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adipose tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within blastocyst hatching ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fat pad development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to dietary excess ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within white fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box-like/WD repeat-containing protein TBL1XR1
Names
TBL1X receptor 1
transducin (beta)-like 1 X-linked receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108941.1 → NP_001102411.1  F-box-like/WD repeat-containing protein TBL1XR1

    See identical proteins and their annotated locations for NP_001102411.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473961
    UniProtKB/TrEMBL
    A6IHE1, D3ZNF4, G3V6G5
    Related
    ENSRNOP00000015573.4, ENSRNOT00000015573.6
    Conserved Domains (3) summary
    cd00200
    Location:164 → 470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:228 → 264
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:7 → 31
    LisH

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    106718811..106857989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102745.1 → XP_038958673.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

    UniProtKB/TrEMBL
    A6IHE1, D3ZNF4, G3V6G5
    Conserved Domains (3) summary
    cd00200
    Location:164 → 470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:228 → 264
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:7 → 31
    LisH

  2. XM_039102747.1 → XP_038958675.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X2

    Conserved Domains (2) summary
    cd00200
    Location:77 → 383
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:141 → 177
    7WD40; WD40 repeat [structural motif]

  3. XM_006232190.4 → XP_006232252.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

    See identical proteins and their annotated locations for XP_006232252.1

    UniProtKB/TrEMBL
    A6IHE1, D3ZNF4, G3V6G5
    Conserved Domains (3) summary
    cd00200
    Location:164 → 470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:228 → 264
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:7 → 31
    LisH

  4. XM_039102748.1 → XP_038958676.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X2

    Conserved Domains (2) summary
    cd00200
    Location:77 → 383
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:141 → 177
    7WD40; WD40 repeat [structural motif]

  5. XM_039102746.2 → XP_038958674.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

    UniProtKB/TrEMBL
    A6IHE1, D3ZNF4, G3V6G5
    Conserved Domains (3) summary
    cd00200
    Location:164 → 470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:228 → 264
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:7 → 31
    LisH

  6. XM_017590991.3 → XP_017446480.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

    UniProtKB/TrEMBL
    A6IHE1, D3ZNF4, G3V6G5
    Conserved Domains (3) summary
    cd00200
    Location:164 → 470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:228 → 264
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:7 → 31
    LisH

  7. XM_017590990.2 → XP_017446479.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

    UniProtKB/TrEMBL
    A6IHE1, D3ZNF4, G3V6G5
    Conserved Domains (3) summary
    cd00200
    Location:164 → 470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:228 → 264
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:7 → 31
    LisH
Nucleotide Protein Strain
Heading Accession and Version

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