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Zbtb24 zinc finger and BTB domain containing 24 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365590, updated on 2-Nov-2024

Summary

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Official Symbol
Zbtb24provided by RGD
Official Full Name
zinc finger and BTB domain containing 24provided by RGD
Primary source
RGD:1306951
See related
EnsemblRapid:ENSRNOG00000000308 AllianceGenome:RGD:1306951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bif1a; ZNF450
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 2. Orthologous to human ZBTB24 (zinc finger and BTB domain containing 24). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 37.0), Spleen (RPKM 26.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zbtb24 in Genome Data Viewer
Location:
20q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (46525982..46546363)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (44943302..44965329)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (46168149..46189806)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene UTP15, small subunit processome component Neighboring gene adenylate kinase 9 Neighboring gene uncharacterized LOC120098942 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 1 Neighboring gene sphingomyelin phosphodiesterase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Bone morphogenetic protein-2 induces expression of murine zinc finger transcription factor ZNF450. Edgar AJ, et al. J Cell Biochem, 2005 Jan 1. PMID 15526281
  2. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 24
Names
bone morphogenetic protein-induced factor 1
zinc finger protein 450

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098667.2 → NP_001092137.2  zinc finger and BTB domain-containing protein 24

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A0A8L2QRY7, A6K719
    Related
    ENSRNOP00000054002.4, ENSRNOT00000057175.4
    Conserved Domains (5) summary
    COG5048
    Location:320 → 479
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:407 → 427
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18212
    Location:14 → 130
    BTB_POZ_ZBTB24_ZNF450; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24)
    pfam13465
    Location:477 → 500
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:295 → 339
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    46525982..46546363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098907.2 → XP_038954835.1  zinc finger and BTB domain-containing protein 24 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QRY7, A6K719
    Conserved Domains (5) summary
    COG5048
    Location:320 → 479
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:407 → 427
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18212
    Location:14 → 130
    BTB_POZ_ZBTB24_ZNF450; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24)
    pfam13465
    Location:477 → 500
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:295 → 339
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  2. XM_063279330.1 → XP_063135400.1  zinc finger and BTB domain-containing protein 24 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3B725.1 GenPept UniProtKB/Swiss-Prot:Q3B725

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