U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CtsL1 Cathepsin L1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36546, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
CtsL1provided by FlyBase
Official Full Name
Cathepsin L1provided by FlyBase
Primary source
FLYBASE:FBgn0013770
Locus tag
Dmel_CG6692
See related
AllianceGenome:FB:FBgn0013770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cath L; CathL; CatL; CATL_DROME; CG6692; CL; cp1; Cp1; CP1; CT20780; Cts1; Cts2; CtsL; CTSL; CysP-1; Dcp-1; DCP-1; Dcp1; DCP1; Dmel\CG6692; fs(2)50Ca
Summary
Enables cysteine-type endopeptidase activity. Involved in proteolysis. Located in fusome and lysosome. Is expressed in several structures, including central nervous system; circulatory system; dorsal closure embryo; embryonic/larval digestive system; and gonad. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L) and CTSV (cathepsin V). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CtsL1 in Genome Data Viewer
Location:
50C18-50C20; 2-68 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13960675..13967981)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9848180..9855486)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Argonaute-1 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L53 Neighboring gene Regulatory particle non-ATPase 13 Neighboring gene uncharacterized protein Neighboring gene Phenylalanyl-tRNA synthetase, mitochondrial Neighboring gene Sulfotransferase 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A putative digestive cysteine proteinase from Drosophila melanogaster is predominantly expressed in the embryonic and larval midgut. Matsumoto I, et al. Eur J Biochem, 1995 Jan 15. PMID 7851441
  2. Cysteine proteinase 1 (CP1), a cathepsin L-like enzyme expressed in the Drosophila melanogaster haemocyte cell line mbn-2. Tryselius Y, et al. Insect Mol Biol, 1997 May. PMID 9099581
  3. P-element-induced male recombination and gene conversion in Drosophila. Preston CR, et al. Genetics, 1996 Dec. PMID 8978049, Free PMC Article
  4. Drosophila CTLA-2-like protein (D/CTLA-2) inhibits cysteine proteinase 1 (CP1), a cathepsin L-like enzyme. Deshapriya RM, et al. Zoolog Sci, 2007 Jan. PMID 17409713
  5. Structure and associated mutational effects of the cysteine proteinase (CP1) gene of Drosophila melanogaster. Gray YH, et al. Insect Mol Biol, 1998 Aug. PMID 9662479

See all (148) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cp1 and cortex glia have roles in in alcohol-related behaviors in Drosophila
    Title: Alcohol sedation in adult Drosophila is regulated by Cysteine proteinase-1 in cortex glia.
  2. Data show that cysteine proteinase 1 (CP1) is expressed in air sac primordium (ASP) and knockdown of CP1 results in suppression of migratory and invasive behavior observed during ASP development.
    Title: A Cathepsin-L is required for invasive behavior during Air Sac Primordium development in Drosophila melanogaster.
  3. Data show the models of the tertiary structures of cathepsin L constructed by using homology modeling methods.
    Title: Structural and functional conservation profiles of novel cathepsin L-like proteins identified in the Drosophila melanogaster genome.
  4. Premature activation of the effector caspase, dcp1, resulted in a disappearance of filamentous actin, rather than the formation of actin bundles, suggesting that dcp-1 activity must be restrained in late oogenesis.
    Title: Stage-specific regulation of caspase activity in drosophila oogenesis.
  5. Drosophila decapping protein 1, dDcp1, is a posterior group gene required for the transport of osk mRNA.
    Title: Drosophila decapping protein 1, dDcp1, is a component of the oskar mRNP complex and directs its posterior localization in the oocyte.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis involved in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in autolysosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fusome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
cathepsin L1
Names
CG6692-PA
CG6692-PC
CG6692-PD
CG6692-PE
Cathepsin-L
Cathepsin-L-like protease
CathepsinL
CtsL1-PA
CtsL1-PC
CtsL1-PD
CtsL1-PE
L-like cysteine protease
cathepsin L
cysteine proteinase 1
cysteine proteinase-1
drosophila cysteine proteinase-1
NP_001188921.1
NP_523735.2
NP_725347.1
NP_725348.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13960675..13967981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166026.3 → NP_725347.1  cathepsin L1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725347.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6SV44
    Related
    FBpp0086718
    Conserved Domains (2) summary
    smart00848
    Location:29 → 88
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:124 → 340
    Peptidase_C1; Papain family cysteine protease

  2. NM_079011.3 → NP_523735.2  cathepsin L1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523735.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O97431, Q5U121, Q95029
    UniProtKB/TrEMBL
    C6SV44
    Related
    FBpp0086719
    Conserved Domains (2) summary
    smart00848
    Location:59 → 118
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:154 → 370
    Peptidase_C1; Papain family cysteine protease

  3. NM_166027.3 → NP_725348.2  cathepsin L1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725348.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6SV44
    Conserved Domains (2) summary
    smart00848
    Location:32 → 85
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:121 → 337
    Peptidase_C1; Papain family cysteine protease

  4. NM_001201992.1 → NP_001188921.1  cathepsin L1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188921.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD48
    Conserved Domains (1) summary
    pfam00112
    Location:32 → 248
    Peptidase_C1; Papain family cysteine protease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JD48 A0A0B4JD48
Q95029.2 Q95029

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous