Chtf8 chromosome transmission fidelity factor 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chtf8provided by RGD
Official Full Name: chromosome transmission fidelity factor 8provided by RGD
Primary source: RGD:1306894
See related: AllianceGenome:RGD:1306894
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ctf8; Derpc; RGD1306894
Summary: Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in positive regulation of DNA-directed DNA polymerase activity. Predicted to be part of Ctf18 RFC-like complex. Orthologous to human CHTF8 (chromosome transmission fidelity factor 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 199.9), Kidney (RPKM 189.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (51691776..51702076, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (34782005..34792306, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (39077580..39087880, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI535550 (e-PCR)
- UniSTS:261435

RH143420 (e-PCR)
- UniSTS:232667

RH129659 (e-PCR)
- UniSTS:212956

AI008492 (e-PCR)
- UniSTS:261627

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to DNA clamp loader activity	ISO Inferred from Sequence Orthology more info
contributes_to DNA clamp loader activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to single-stranded DNA helicase activity	ISO Inferred from Sequence Orthology more info
contributes_to single-stranded DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid cohesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-directed DNA polymerase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-directed DNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Ctf18 RFC-like complex	ISO Inferred from Sequence Orthology more info
part_of Ctf18 RFC-like complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: chromosome transmission fidelity protein 8 homolog

Names: CTF8, chromosome transmission fidelity factor 8 homolog; chromosome transmission fidelity factor 8 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001194951.1 → NP_001181880.1 chromosome transmission fidelity protein 8 homolog

See identical proteins and their annotated locations for NP_001181880.1

Status: VALIDATED

Source sequence(s)

AI044989, JAXUCZ010000019

UniProtKB/Swiss-Prot

P0C6T1

Conserved Domains (1) summary

pfam09696
Location:13 → 113

Ctf8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

51691776..51702076 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001126495.2: Suppressed sequence

Description

NM_001126495.2: This RefSeq was temporarily suppressed because the transcript was partial and the protein coding region was erroneously annotated in the 3'' UTR.