cid centromere identifier [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cidprovided by FlyBase
Official Full Name: centromere identifierprovided by FlyBase
Primary source: FLYBASE:FBgn0040477
Locus tag: Dmel_CG13329
See related: AllianceGenome:FB:FBgn0040477
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE21270; cenH3; CenH3; CENH3; CenH3[Cid]; CenH3[CID]; cenp-a; Cenp-A; CENP-A; CENP-A/Cid; CENP-A/CID; CENP-A/Cnp1; cenpA; CenpA; CENPA; CenpA/CID; CG13329; Cid; CID; CID/CENP-A; Cid[Mel]; dCENP-A; dCenpA; Dmel\CG13329
Summary: Predicted to enable DNA binding activity and protein heterodimerization activity. Involved in chromosome organization and spindle assembly. Located in kinetochore. Part of CENP-A containing nucleosome and inner kinetochore. Is expressed in female pronucleus; germarium; male pronucleus; spermatid; and spermatocyte. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 50A11-50A11; 2-68 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (13485617..13486631)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (9373122..9374136)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CENP-C functions in centromere assembly, the maintenance of CENP-A asymmetry and epigenetic age in Drosophila germline stem cells.
Title: CENP-C functions in centromere assembly, the maintenance of CENP-A asymmetry and epigenetic age in Drosophila germline stem cells.
Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1.
Title: Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1.
Spt6 is a maintenance factor for centromeric CENP-A.
Title: Spt6 is a maintenance factor for centromeric CENP-A.
Targeted De Novo Centromere Formation in Drosophila Reveals Plasticity and Maintenance Potential of CENP-A Chromatin.
Title: Targeted De Novo Centromere Formation in Drosophila Reveals Plasticity and Maintenance Potential of CENP-A Chromatin.
The data show that Drosophila CENP-A has no intrinsic specificity for centromeric chromatin and utilizes separate loading mechanisms for its incorporation into centromeric and ectopic sites. This suggests that the specific association and availability of CENP-A interacting factors are the major determinants of CENP-A loading specificity.
Title: Localization of Drosophila CENP-A to non-centromeric sites depends on the NuRD complex.
Modulation of the phosphorylation state of S20 may provide the cells with a means to fine-tune CENP-A levels in order to prevent deleterious loading to extra-centromeric sites.
Title: Phosphorylation of Drosophila CENP-A on serine 20 regulates protein turn-over and centromere-specific loading.
CENP-A levels inversely correlate with mitosis duration suggesting crosstalk of CENP-A loading with the regulatory machinery of mitosis. Mitosis length is influenced by the spindle assembly checkpoint (SAC), and authors found that CAL1 interacts with the SAC protein and RZZ complex component Zw10 and thus constitutes the anchor for the recruitment of RZZ.
Title: The checkpoint protein Zw10 connects CAL1-dependent CENP-A centromeric loading and mitosis duration in Drosophila cells.
results suggest that, whereas SCF(Ppa) targets the fraction of CENP-A(CID) that is not in complex with Cal1, APC/C(Cdh1) mediates also degradation of the Cal1-CENP-A(CID) complex and, thus, likely contributes to the regulation of centromeric CENP-A(CID) deposition
Title: The E3-ligases SCFPpa and APC/CCdh1 co-operate to regulate CENP-ACID expression across the cell cycle.
Cid duplication (leading to Cid6) within the Drosophila subgenus and show that not only Cid, but also Cenp-C is duplicated in the entire subgenus.
Title: Concurrent Duplication of Drosophila Cid and Cenp-C Genes Resulted in Accelerated Evolution and Male Germline-Biased Expression of the New Copies.
NLP and HMR largely co-localize in domains that are immediately adjacent to, yet distinct from centromere domains defined by the centromeric histone dCENP-A.
Title: Oligomerization of Drosophila Nucleoplasmin-Like Protein is required for its centromere localization.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in kinetochore assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kinetochore organization	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CENP-A containing nucleosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
part_of inner kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
part_of nucleosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	IPI Inferred from Physical Interaction more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: centromere identifier

Names: CG13329-PA; centromere identifier protein; centromere protein A; centromeric histone H3; cid-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

13485617..13486631

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079006.4 → NP_523730.2 centromere identifier [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523730.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YUD4, Q7YUD5, Q8MQP5, Q9NG62, Q9V6Q2

UniProtKB/TrEMBL

H0RNB3

Related

FBpp0086787

Conserved Domains (1) summary

cl23735
Location:135 → 219

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...