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Ero1b endoplasmic reticulum oxidoreductase 1 beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 364755, updated on 2-Nov-2024

Summary

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Symbol
Ero1bprovided by RGD
Full Name
endoplasmic reticulum oxidoreductase 1 betaprovided by RGD
Primary source
RGD:1563548
See related
EnsemblRapid:ENSRNOG00000002609 AllianceGenome:RGD:1563548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ero1lb; RGD1563548
Summary
Predicted to enable protein-disulfide reductase activity and thiol oxidase activity. Predicted to be involved in protein folding in endoplasmic reticulum. Predicted to act upstream of or within several processes, including cell redox homeostasis; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and protein maturation. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum lumen and endoplasmic reticulum membrane. Orthologous to human ERO1B (endoplasmic reticulum oxidoreductase 1 beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 233.1), Spleen (RPKM 124.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ero1b in Genome Data Viewer
Location:
17q12.3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (92913696..92987401)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (85861086..86003244)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (90709394..90783110, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene sperm motility kinase X-like Neighboring gene EDAR associated via death domain Neighboring gene G protein-coupled receptor 137B Neighboring gene nidogen 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis. Zito E, et al. J Cell Biol, 2010 Mar 22. PMID 20308425, Free PMC Article
  2. Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox. Avezov E, et al. J Cell Biol, 2013 Apr 15. PMID 23589496, Free PMC Article
  3. Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice. Zito E, et al. Mol Cell, 2012 Oct 12. PMID 22981861, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables disulfide oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables thiol oxidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within insulin processing ISO
Inferred from Sequence Orthology
more info
  
involved_in insulin processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-proline hydroxylation to 4-hydroxy-L-proline ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein maturation by protein folding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ERO1-like protein beta
Names
ERO1-like beta
endoplasmic reticulum oxidoreductase beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191893.2 → NP_001178822.1  ERO1-like protein beta isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A8I6A593
    Related
    ENSRNOP00000086032.2, ENSRNOT00000113322.2
    Conserved Domains (1) summary
    pfam04137
    Location:56 → 449
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  2. NM_001415676.1 → NP_001402605.1  ERO1-like protein beta isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    Related
    ENSRNOP00000075470.3, ENSRNOT00000085669.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    92913696..92987401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095982.2 → XP_038951910.1  ERO1-like protein beta isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBH6, A0A8I6GLG0
    Conserved Domains (1) summary
    pfam04137
    Location:23 → 421
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  2. XM_008771876.4 → XP_008770098.1  ERO1-like protein beta isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBH6, A0A8I6GLG0
    Related
    ENSRNOP00000096082.1, ENSRNOT00000100413.2
    Conserved Domains (1) summary
    pfam04137
    Location:23 → 421
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

  3. XM_063276672.1 → XP_063132742.1  ERO1-like protein beta isoform X1

    UniProtKB/TrEMBL
    A0A0G2KAP1

  4. XM_063276675.1 → XP_063132745.1  ERO1-like protein beta isoform X5

    Related
    ENSRNOP00000086364.1, ENSRNOT00000115419.2

  5. XM_063276674.1 → XP_063132744.1  ERO1-like protein beta isoform X4

  6. XM_063276673.1 → XP_063132743.1  ERO1-like protein beta isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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