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CG4676 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36465, updated on 2-Nov-2024

Summary

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Official Symbol
CG4676provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033815
Locus tag
Dmel_CG4676
See related
AllianceGenome:FB:FBgn0033815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4676
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in adult head; adult nervous system; larval brain; and larval central nervous system. Orthologous to human ZDHHC24 (zinc finger DHHC-type containing 24). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See CG4676 in Genome Data Viewer
Location:
49F11-49F11; 2-68 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13235980..13237055)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9123485..9124560)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene fates-shifted Neighboring gene Quiescin sulfhydryl oxidase 1 Neighboring gene uncharacterized protein Neighboring gene Glutathione S transferase E14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The S-palmitoylome and DHHC-PAT interactome of Drosophila melanogaster S2R+ cells indicate a high degree of conservation to mammalian palmitoylomes. Porcellato E, et al. PLoS One, 2022. PMID 35960718, Free PMC Article
  2. Neuronal expression in Drosophila of an evolutionarily conserved metallophosphodiesterase reveals pleiotropic roles in longevity and odorant response. Gupta K, et al. PLoS Genet, 2023 Sep. PMID 37733787, Free PMC Article
  3. Gain of function screen of PATs reveals an essential role of Hip14 in Drosophila host defense. Deng Z, et al. J Genet Genomics, 2023 Dec. PMID 37343788
  4. Pri peptides are mediators of ecdysone for the temporal control of development. Chanut-Delalande H, et al. Nat Cell Biol, 2014 Nov. PMID 25344753
  5. The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases. Bannan BA, et al. Fly (Austin), 2008 Jul-Aug. PMID 18719403, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG4676-PA
NP_610853.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13235980..13237055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137009.3 → NP_610853.1  uncharacterized protein Dmel_CG4676 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610853.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0IGS7
    Related
    FBpp0086856
    Conserved Domains (1) summary
    pfam01529
    Location:99 → 232
    zf-DHHC; DHHC palmitoyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0IGS7 Q0IGS7

Gene LinkOut

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