Micu3 mitochondrial calcium uptake family, member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Micu3provided by RGD
Official Full Name: mitochondrial calcium uptake family, member 3provided by RGD
Primary source: RGD:1563411
See related: EnsemblRapid:ENSRNOG00000012767 AllianceGenome:RGD:1563411
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Efha2
Summary: Enables calcium ion sensor activity. Involved in calcium import into the mitochondrion. Acts upstream of with a positive effect on positive regulation of neurotransmitter secretion. Predicted to be located in mitochondrion. Predicted to be part of uniplex complex. Orthologous to human MICU3 (mitochondrial calcium uptake family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 191.6), Kidney (RPKM 38.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (58624702..58714302, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (51919859..52010705, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (55043051..55133080, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of mitochondrial calcium uptake family 3 attenuates secondary brain injury after intracerebral hemorrhage in rats.
Title: Downregulation of mitochondrial calcium uptake family 3 attenuates secondary brain injury after intracerebral hemorrhage in rats.

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:495813

RH131756 (e-PCR)
- UniSTS:215039

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion sensor activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion sensor activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium import into the mitochondrion	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_positive_effect positive regulation of neurotransmitter secretion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
part_of uniplex complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calcium uptake protein 3, mitochondrial

Names: EF hand domain family, member A2; EF-hand domain-containing family member A2; mitochondrial uptake family, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191892.1 → NP_001178821.1 calcium uptake protein 3, mitochondrial

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0AAK3FFS0

Related

ENSRNOP00000017025.6, ENSRNOT00000017025.9

Conserved Domains (3) summary

pfam05763
Location:325 → 413

DUF835; Protein of unknown function (DUF835)

pfam13499
Location:421 → 468

EF-hand_7; EF-hand domain pair

pfam13833
Location:418 → 471

EF-hand_8; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

58624702..58714302 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094721.2 → XP_038950649.1 calcium uptake protein 3, mitochondrial isoform X3

UniProtKB/TrEMBL

A0AAK3H8H3

Related

ENSRNOP00000082387.1, ENSRNOT00000102161.2

Conserved Domains (1) summary

cd16175
Location:229 → 459

EFh_MICU3; EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and similar proteins
XM_008771293.4 → XP_008769515.1 calcium uptake protein 3, mitochondrial isoform X2

UniProtKB/TrEMBL

A0AAK3HSM7

Related

ENSRNOP00000088716.1, ENSRNOT00000099337.2

Conserved Domains (2) summary

PTZ00183
Location:231 → 346

PTZ00183; centrin; Provisional

pfam13833
Location:429 → 482

EF-hand_8; EF-hand domain pair
XM_006253200.5 → XP_006253262.1 calcium uptake protein 3, mitochondrial isoform X1

UniProtKB/Swiss-Prot

A0A8I5ZTV9, A0A8I6A2H6, A0A8I6AA12, D3ZG95

Related

ENSRNOP00000087041.1, ENSRNOT00000098345.2

Conserved Domains (1) summary

pfam13833
Location:442 → 495

EF-hand_8; EF-hand domain pair
XM_063275597.1 → XP_063131667.1 calcium uptake protein 3, mitochondrial isoform X4