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Asb3 ankyrin repeat and SOCS box-containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364227, updated on 2-Nov-2024

Summary

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Official Symbol
Asb3provided by RGD
Official Full Name
ankyrin repeat and SOCS box-containing 3provided by RGD
Primary source
RGD:1308462
See related
EnsemblRapid:ENSRNOG00000032471 AllianceGenome:RGD:1308462
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to several human genes including ASB3 (ankyrin repeat and SOCS box containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 131.7), Thymus (RPKM 116.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Asb3 in Genome Data Viewer
Location:
14q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (108860318..108988939)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (104659406..104788032)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (115352716..115446618)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 4 Neighboring gene G protein-coupled receptor 75 Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene ChaC glutathione specific gamma-glutamylcyclotransferase 2 Neighboring gene uncharacterized LOC134481883 Neighboring gene ubiquitin-conjugating enzyme E2 N-like Neighboring gene zinc finger protein 950 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 3
Names
ankyrin repeat and SOCS box-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108864.1 → NP_001102334.1  ankyrin repeat and SOCS box protein 3

    See identical proteins and their annotated locations for NP_001102334.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473996
    UniProtKB/TrEMBL
    A0A0G2KA67, A6JQD7, D3ZJN4
    Related
    ENSRNOP00000107365.1, ENSRNOT00000173327.1
    Conserved Domains (5) summary
    PHA02874
    Location:52 → 345
    PHA02874; ankyrin repeat protein; Provisional
    cd03722
    Location:458 → 508
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:146 → 176
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:17 → 63
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:150 → 240
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    108860318..108988939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092258.2 → XP_038948186.1  ankyrin repeat and SOCS box protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2KA67, A6JQD7, D3ZJN4
    Conserved Domains (5) summary
    PHA02874
    Location:52 → 345
    PHA02874; ankyrin repeat protein; Provisional
    cd03722
    Location:458 → 508
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:146 → 176
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:17 → 63
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:150 → 240
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_063273444.1 → XP_063129514.1  ankyrin repeat and SOCS box protein 3 isoform X4

  3. XM_063273443.1 → XP_063129513.1  ankyrin repeat and SOCS box protein 3 isoform X1

    Related
    ENSRNOP00000075281.3, ENSRNOT00000079169.3

  4. XM_039092261.2 → XP_038948189.1  ankyrin repeat and SOCS box protein 3 isoform X6

    Conserved Domains (3) summary
    PHA02874
    Location:32 → 299
    PHA02874; ankyrin repeat protein; Provisional
    sd00045
    Location:157 → 187
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:161 → 251
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_039092259.2 → XP_038948187.1  ankyrin repeat and SOCS box protein 3 isoform X3

    UniProtKB/TrEMBL
    D3ZJN4
    Conserved Domains (4) summary
    PHA02874
    Location:63 → 356
    PHA02874; ankyrin repeat protein; Provisional
    sd00045
    Location:157 → 187
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:28 → 74
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:161 → 251
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_063273445.1 → XP_063129515.1  ankyrin repeat and SOCS box protein 3 isoform X5

  7. XM_039092257.2 → XP_038948185.1  ankyrin repeat and SOCS box protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2KA67, A6JQD7, D3ZJN4
    Conserved Domains (5) summary
    PHA02874
    Location:52 → 345
    PHA02874; ankyrin repeat protein; Provisional
    cd03722
    Location:458 → 508
    SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
    sd00045
    Location:146 → 176
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:17 → 63
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:150 → 240
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version

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