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AspRS Aspartyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36420, updated on 2-Nov-2024

Summary

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Official Symbol
AspRSprovided by FlyBase
Official Full Name
Aspartyl-tRNA synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0002069
Locus tag
Dmel_CG3821
See related
AllianceGenome:FB:FBgn0002069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aaRS(Asp); aats-asp; Aats-asp; Aats-Asp; anon-EST:Liang-2.49; cDNA1; CG3821; clone 2.49; DARS; Dmel\CG3821; DRS; l(2)49Db; l(2)k04508; l(2)v27; l(2)vr1; poney; vr1
Summary
Predicted to enable RNA binding activity and aspartate-tRNA ligase activity. Predicted to be involved in aspartyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in adult head; adult heart; embryonic/larval salivary gland; and organism. Orthologous to human DARS1 (aspartyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See AspRS in Genome Data Viewer
Location:
49D6-49D7; 2-67 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12877004..12883168)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8764509..8770673)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43469 Neighboring gene antisense RNA:CR43468 Neighboring gene Beta-alanine transporter Neighboring gene Lifeguard Neighboring gene N-methyl-D-aspartate receptor-associated protein Neighboring gene antisense RNA:CR45141 Neighboring gene vestigial Neighboring gene long non-coding RNA:CR46237

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. bicaudal encodes the Drosophila beta NAC homolog, a component of the ribosomal translational machinery*. Markesich DC, et al. Development, 2000 Feb. PMID 10631177
  2. SUMOylation of Arginyl tRNA Synthetase Modulates the Drosophila Innate Immune Response. Nayak P, et al. Front Cell Dev Biol, 2021. PMID 34660574, Free PMC Article
  3. The multienzyme complex containing nine aminoacyl-tRNA synthetases is ubiquitous from Drosophila to mammals. Kerjan P, et al. Biochim Biophys Acta, 1994 Apr 21. PMID 8161568
  4. Mutations in the predicted aspartyl tRNA synthetase of Drosophila are lethal and function as dosage-sensitive maternal modifiers of the sex determination gene Sex-lethal. Stitzinger SM, et al. Mol Gen Genet, 1999 Feb. PMID 10071220
  5. Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep. Harbison ST, et al. Nat Genet, 2009 Mar. PMID 19234472, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartate-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartate-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables aspartate-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aspartyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aspartyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in aspartyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Aspartyl-tRNA synthetase
Names
AspRS-PA
AspRS-PB
AspRS-PC
CG3821-PA
CG3821-PB
CG3821-PC
lethal(2)49Db
NP_001260930.1
NP_001260931.1
NP_476609.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12877004..12883168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274002.2 → NP_001260931.1  Aspartyl-tRNA synthetase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260931.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K0E6, Q9XYM1
    Conserved Domains (3) summary
    PLN02850
    Location:49 → 531
    PLN02850; aspartate-tRNA ligase
    cd00776
    Location:203 → 527
    AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
    cd04320
    Location:89 → 187
    AspRS_cyto_N; AspRS_cyto_N: N-terminal, anticodon recognition domain of the type found in Saccharomyces cerevisiae and human cytoplasmic aspartyl-tRNA synthetase (AspRS). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...

  2. NM_057261.4 → NP_476609.1  Aspartyl-tRNA synthetase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476609.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K0E6, Q9XYM1
    Related
    FBpp0086897
    Conserved Domains (3) summary
    PLN02850
    Location:49 → 531
    PLN02850; aspartate-tRNA ligase
    cd00776
    Location:203 → 527
    AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
    cd04320
    Location:89 → 187
    AspRS_cyto_N; AspRS_cyto_N: N-terminal, anticodon recognition domain of the type found in Saccharomyces cerevisiae and human cytoplasmic aspartyl-tRNA synthetase (AspRS). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...

  3. NM_001274001.1 → NP_001260930.1  Aspartyl-tRNA synthetase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260930.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K0E6, Q9XYM1
    Conserved Domains (3) summary
    PLN02850
    Location:49 → 531
    PLN02850; aspartate-tRNA ligase
    cd00776
    Location:203 → 527
    AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
    cd04320
    Location:89 → 187
    AspRS_cyto_N; AspRS_cyto_N: N-terminal, anticodon recognition domain of the type found in Saccharomyces cerevisiae and human cytoplasmic aspartyl-tRNA synthetase (AspRS). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K0E6 Q7K0E6
Q9XYM1 Q9XYM1

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