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muskelin muskelin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36386, updated on 2-Nov-2024

Summary

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Official Symbol
muskelinprovided by FlyBase
Official Full Name
muskelinprovided by FlyBase
Primary source
FLYBASE:FBgn0033757
Locus tag
Dmel_CG8811
See related
AllianceGenome:FB:FBgn0033757
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8811; Dmel\CG8811; DmMK; Muskelin
Summary
Involved in oocyte maturation and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm. Part of GID complex. Is expressed in organism. Orthologous to human MKLN1 (muskelin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See muskelin in Genome Data Viewer
Location:
49B10-49B10; 2-67 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12628697..12632378, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8516202..8519883, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene spt4 Neighboring gene uncharacterized protein Neighboring gene Mevalonate kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Quantitative proteomics reveals the dynamics of protein changes during Drosophila oocyte maturation and the oocyte-to-embryo transition. Kronja I, et al. Proc Natl Acad Sci U S A, 2014 Nov 11. PMID 25349405, Free PMC Article
  2. Characterization of a Drosophila melanogaster orthologue of muskelin. Adams JC. Gene, 2002 Sep 4. PMID 12384287
  3. The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition. Zavortink M, et al. Elife, 2020 Jun 23. PMID 32573431, Free PMC Article
  4. A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium. Shao W, et al. PLoS One, 2010 Apr 1. PMID 20368978, Free PMC Article
  5. Proteomic Analysis of Red Ginseng on Prolonging the Life Span of Male Drosophila melanogaster. Hou W, et al. Front Pharmacol, 2021. PMID 34177563, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in oocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell-matrix adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of GID complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
muskelin
Names
CG8811-PA
CG8811-PB
CG8811-PC
muskelin-PA
muskelin-PB
muskelin-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12628697..12632378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273992.1 → NP_001260921.1  muskelin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260921.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFH1, Q8MR83
    Conserved Domains (4) summary
    smart00668
    Location:240 → 292
    CTLH; C-terminal to LisH motif
    sd00038
    Location:299 → 349
    Kelch; KELCH repeat [structural motif]
    pfam06588
    Location:44 → 241
    Muskelin_N; Muskelin N-terminus
    pfam13418
    Location:299 → 341
    Kelch_4; Galactose oxidase, central domain

  2. NM_136957.3 → NP_610801.1  muskelin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610801.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9A5, Q8MR83
    Related
    FBpp0086999
    Conserved Domains (4) summary
    smart00668
    Location:240 → 292
    CTLH; C-terminal to LisH motif
    sd00038
    Location:299 → 350
    Kelch; KELCH repeat [structural motif]
    pfam06588
    Location:44 → 241
    Muskelin_N; Muskelin N-terminus
    pfam13415
    Location:313 → 362
    Kelch_3; Galactose oxidase, central domain

  3. NM_165928.1 → NP_725200.1  muskelin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725200.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9A5, Q8MR83
    Related
    FBpp0086998, FBtr0087885
    Conserved Domains (4) summary
    smart00668
    Location:240 → 292
    CTLH; C-terminal to LisH motif
    sd00038
    Location:299 → 350
    Kelch; KELCH repeat [structural motif]
    pfam06588
    Location:44 → 241
    Muskelin_N; Muskelin N-terminus
    pfam13415
    Location:313 → 362
    Kelch_3; Galactose oxidase, central domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFH1 A0A0B4KFH1
Q0E9A5 Q0E9A5
Q8MR83 Q8MR83
Q8WSN1 Q8WSN1

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