Map2k7 mitogen activated protein kinase kinase 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Map2k7provided by RGD
Full Name: mitogen activated protein kinase kinase 7provided by RGD
Primary source: RGD:1560043
See related: EnsemblRapid:ENSRNOG00000001047 AllianceGenome:RGD:1560043
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: JNKK; Mek7; Mkk7; Jnkk2; Mapkk7
Summary: Enables several functions, including ATP binding activity; JUN kinase kinase activity; and magnesium ion binding activity. Involved in several processes, including MAPK cascade; cellular response to sorbitol; and positive regulation of JNK cascade. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; lung carcinoma; and lung non-small cell carcinoma. Orthologous to human MAP2K7 (mitogen-activated protein kinase kinase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 115.0), Muscle (RPKM 104.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (7389032..7398377)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (2591312..2600534)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (2546278..2555310, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MKK7 down-regulation is a new therapeutic strategy against excitotoxicity and cerebral ischemia.
Title: Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury.
MKK7gamma1 affects the function and activity of individual JNK isoforms and the formation of their signalosomes.
Title: Specific regulation of JNK signalling by the novel rat MKK7gamma1 isoform.
JNK1/2 activation is associated with endogenous NO in response to ischemic insult.
Title: Activation of c-Jun N-terminal kinase 1/2 regulated by nitric oxide is associated with neuronal survival in hippocampal neurons in a rat model of ischemia.
MKK7gamma1 is a cue molecule for antagonisation of basic cell programmes and subsequent loss of control with either ongoing proliferation or enhanced cell death.
Title: MKK7γ1 reverses nerve growth factor signals: proliferation and cell death instead of neuritogenesis and protection.
Map2k7 activation, translocation and binding to Jun N-terminal kinase (JNK)-interacting protein (JIP)-1 is closely associated with reactive oxygen species and might play a pivotal role in the activation of JNK signaling in brain ischemic injury. [Map2k7]
Title: Activated mitogen-activated protein kinase kinase 7 redistributes to the cytosol and binds to Jun N-terminal kinase-interacting protein 1 involving oxidative stress during early reperfusion in rat hippocampal CA1 region.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables JUN kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to sorbitol	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of telomere maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of motor neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of motor neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in response to UV	IEA Inferred from Electronic Annotation more info
involved_in response to UV	ISO Inferred from Sequence Orthology more info
involved_in response to heat	IEA Inferred from Electronic Annotation more info
involved_in response to heat	ISO Inferred from Sequence Orthology more info
involved_in response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to osmotic stress	IEA Inferred from Electronic Annotation more info
involved_in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in response to stress	IEA Inferred from Electronic Annotation more info
involved_in response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to wounding	ISO Inferred from Sequence Orthology more info
involved_in stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in stress-activated MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dual specificity mitogen-activated protein kinase kinase 7

Names: JNK kinase 2; JNK-activating kinase 2; JNKK 2; MAP kinase kinase 7; MAPK/ERK kinase 7; MAPKK 7; MEK 7; c-Jun N-terminal kinase kinase 2

NP_001020596.1

EC 2.7.12.2

NP_001388136.1

EC 2.7.12.2

XP_006248831.1

EC 2.7.12.2

XP_008767207.1

EC 2.7.12.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025425.2 → NP_001020596.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 1

See identical proteins and their annotated locations for NP_001020596.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

Q4KSH7

UniProtKB/TrEMBL

A6KQ61, A6KQ65

Related

ENSRNOP00000086269.1, ENSRNOT00000104881.2

Conserved Domains (1) summary

cd06618
Location:104 → 400

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
NM_001401207.1 → NP_001388136.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A0G2K2A1, A6KQ64, D3XAM6

Related

ENSRNOP00000072160.1, ENSRNOT00000084460.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

7389032..7398377

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006248769.4 → XP_006248831.1 dual specificity mitogen-activated protein kinase kinase 7 isoform X1

See identical proteins and their annotated locations for XP_006248831.1

UniProtKB/TrEMBL

A6KQ61, A6KQ62

Conserved Domains (2) summary

smart00220
Location:137 → 396

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06618
Location:120 → 416

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
XM_008768985.4 → XP_008767207.1 dual specificity mitogen-activated protein kinase kinase 7 isoform X2

See identical proteins and their annotated locations for XP_008767207.1

UniProtKB/TrEMBL

A0A8L2UMW0, A6KQ61, A6KQ63

Related

ENSRNOP00000058535.4, ENSRNOT00000061821.5

Conserved Domains (2) summary

smart00220
Location:121 → 380

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06618
Location:104 → 400

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7