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achi achintya [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36373, updated on 10-May-2024

Summary

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Official Symbol
achiprovided by FlyBase
Official Full Name
achintyaprovided by FlyBase
Primary source
FLYBASE:FBgn0033749
Locus tag
Dmel_CG8819
See related
AllianceGenome:FB:FBgn0033749
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ach; Achi; achi/vis; CG8819; Dmel\CG8819; dTGIF; dTGIFa; dTGIFb; TGIF; vis; zaa
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in positive regulation of transcription, DNA-templated and spermatogenesis. Located in nucleus. Is expressed in several structures, including ectoderm; embryonic brain; extended germ band embryo; gonad; and wing disc. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 4. Orthologous to several human genes including TGIF1 (TGFB induced factor homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See achi in Genome Data Viewer
Location:
49A10-49A10; 2-67 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12511534..12515062, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8399039..8402567, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene fused lobes Neighboring gene stanley-cup Neighboring gene vismay Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development. Xia S, et al. PLoS Genet, 2021 Jul. PMID 34242211, Free PMC Article
  2. Drosophila TGIF proteins are transcriptional activators. Hyman CA, et al. Mol Cell Biol, 2003 Dec. PMID 14645536, Free PMC Article
  3. Dynamics and stage-specificity of between-population gene expression divergence in the Drosophila melanogaster larval fat body. Glaser-Schmitt A, et al. PLoS Genet, 2023 Apr. PMID 37099612, Free PMC Article
  4. Transgenic analyses of TGIF family proteins in Drosophila imply their role in cell growth. Wang Y, et al. J Genet Genomics, 2008 Aug. PMID 18721782
  5. On the Regulatory Evolution of New Genes Throughout Their Life History. Zhang JY, et al. Mol Biol Evol, 2019 Jan 1. PMID 30395322

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
achintya
Names
CG8819-PA
CG8819-PC
CG8819-PD
achi-PA
achi-PC
achi-PD
zuker-aly-like a

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12511534..12515062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165911.2 → NP_725182.1  achintya, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725182.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JR08
    Related
    FBpp0087054
    Conserved Domains (1) summary
    pfam05920
    Location:111 → 150
    Homeobox_KN; Homeobox KN domain

  2. NM_165912.2 → NP_725183.1  achintya, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725183.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z916
    Related
    FBpp0087053
    Conserved Domains (1) summary
    pfam05920
    Location:111 → 150
    Homeobox_KN; Homeobox KN domain

  3. NM_001299423.1 → NP_001286352.1  achintya, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286352.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z916
    Conserved Domains (1) summary
    pfam05920
    Location:111 → 150
    Homeobox_KN; Homeobox KN domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z916 A1Z916
Q7JR08 Q7JR08

Gene LinkOut

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