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Zpbp2 zona pellucida binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363676, updated on 17-Aug-2024

Summary

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Official Symbol
Zpbp2provided by RGD
Official Full Name
zona pellucida binding protein 2provided by RGD
Primary source
RGD:1549726
See related
EnsemblRapid:ENSRNOG00000007255 AllianceGenome:RGD:1549726
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in acrosome assembly and binding activity of sperm to zona pellucida. Predicted to act upstream of or within membrane lipid metabolic process and regulation of gene expression. Predicted to be located in cell body. Predicted to be part of zona pellucida receptor complex. Predicted to be active in acrosomal vesicle. Orthologous to human ZPBP2 (zona pellucida binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 72.3), Thymus (RPKM 19.1) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zpbp2 in Genome Data Viewer
Location:
10q31
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (84055184..84063776)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83558772..83567511)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86513645..86523375)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene IKAROS family zinc finger 3 Neighboring gene uncharacterized LOC134480865 Neighboring gene U6 spliceosomal RNA Neighboring gene ORMDL sphingolipid biosynthesis regulator 3 Neighboring gene leucine rich repeat containing 3C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion. Kanagaratham C, et al. Mamm Genome, 2018 Apr. PMID 29536159
  2. Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Lin YN, et al. Mol Cell Biol, 2007 Oct. PMID 17664285, Free PMC Article
  3. The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction. Dun MD, et al. J Biol Chem, 2011 Oct 21. PMID 21880732, Free PMC Article
  4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in acrosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acrosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within binding of sperm to zona pellucida ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within membrane lipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sphingolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cell body ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of zona pellucida receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of zona pellucida receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zona pellucida-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007011.1 → NP_001007012.1  zona pellucida-binding protein 2 precursor

    See identical proteins and their annotated locations for NP_001007012.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082007
    UniProtKB/Swiss-Prot
    Q6X781, Q6X782
    Related
    ENSRNOP00000009535.5, ENSRNOT00000009535.8
    Conserved Domains (1) summary
    pfam07354
    Location:55 → 326
    Sp38; Zona-pellucida-binding protein (Sp38)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    84055184..84063776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269546.1 → XP_063125616.1  zona pellucida-binding protein 2 isoform X11

  2. XM_063269544.1 → XP_063125614.1  zona pellucida-binding protein 2 isoform X7

  3. XM_063269545.1 → XP_063125615.1  zona pellucida-binding protein 2 isoform X8

  4. XM_039086510.2 → XP_038942438.1  zona pellucida-binding protein 2 isoform X12

    Conserved Domains (1) summary
    pfam07354
    Location:78 → 115
    Sp38; Zona-pellucida-binding protein (Sp38)

  5. XM_063269541.1 → XP_063125611.1  zona pellucida-binding protein 2 isoform X4

  6. XM_063269540.1 → XP_063125610.1  zona pellucida-binding protein 2 isoform X2

  7. XM_039086508.2 → XP_038942436.1  zona pellucida-binding protein 2 isoform X9

    Conserved Domains (1) summary
    pfam07354
    Location:94 → 169
    Sp38; Zona-pellucida-binding protein (Sp38)

  8. XM_039086511.2 → XP_038942439.1  zona pellucida-binding protein 2 isoform X13

    Conserved Domains (1) summary
    pfam07354
    Location:39 → 157
    Sp38; Zona-pellucida-binding protein (Sp38)

  9. XM_063269539.1 → XP_063125609.1  zona pellucida-binding protein 2 isoform X1

  10. XM_039086507.2 → XP_038942435.1  zona pellucida-binding protein 2 isoform X3

    Conserved Domains (1) summary
    pfam07354
    Location:149 → 242
    Sp38; Zona-pellucida-binding protein (Sp38)

  11. XM_006247387.5 → XP_006247449.1  zona pellucida-binding protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZK31
    Related
    ENSRNOP00000076458.1, ENSRNOT00000105871.2
    Conserved Domains (1) summary
    pfam07354
    Location:55 → 253
    Sp38; Zona-pellucida-binding protein (Sp38)

  12. XM_039086509.2 → XP_038942437.1  zona pellucida-binding protein 2 isoform X10

    Conserved Domains (1) summary
    pfam07354
    Location:78 → 199
    Sp38; Zona-pellucida-binding protein (Sp38)

  13. XM_063269542.1 → XP_063125612.1  zona pellucida-binding protein 2 isoform X5

    UniProtKB/TrEMBL
    A6HIT1
    Related
    ENSRNOP00000048783.3, ENSRNOT00000048647.6

  14. XM_006247385.5 → XP_006247447.1  zona pellucida-binding protein 2 isoform X5

    See identical proteins and their annotated locations for XP_006247447.1

    UniProtKB/TrEMBL
    A6HIT1
    Conserved Domains (1) summary
    pfam07354
    Location:1 → 272
    Sp38; Zona-pellucida-binding protein (Sp38)

  15. XM_063269543.1 → XP_063125613.1  zona pellucida-binding protein 2 isoform X5

    UniProtKB/TrEMBL
    A6HIT1

  16. XM_006247384.5 → XP_006247446.1  zona pellucida-binding protein 2 isoform X5

    See identical proteins and their annotated locations for XP_006247446.1

    UniProtKB/TrEMBL
    A6HIT1
    Conserved Domains (1) summary
    pfam07354
    Location:1 → 272
    Sp38; Zona-pellucida-binding protein (Sp38)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6X782.1 GenPept UniProtKB/Swiss-Prot:Q6X782

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