Lac Lachesin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lacprovided by FlyBase
Official Full Name: Lachesinprovided by FlyBase
Primary source: FLYBASE:FBgn0010238
Locus tag: Dmel_CG12369
See related: AllianceGenome:FB:FBgn0010238
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bulb; CG12369; CT24921; Dmel\CG12369; l(2)k11012; l(2)k11012b; lac
Summary: Enables protein homodimerization activity. Involved in several processes, including cell adhesion involved in heart morphogenesis; homophilic cell adhesion via plasma membrane adhesion molecules; and regulation of tube architecture, open tracheal system. Located in septate junction. Is expressed in several structures, including ectoderm; ectoderm anlage; extended germ band embryo; neuron projection bundle; and presumptive embryonic/larval system. Orthologous to human NEGR1 (neuronal growth regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12453190..12465630)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (8340695..8353135)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Lac co-localizes with Septate Junction proteins and accumulates specifically at this type of cellular junction.
Title: Lachesin is a component of a septate junction-based mechanism that controls tube size and epithelial integrity in the Drosophila tracheal system.
Here, we report that Drosophila Lachesin (Lac), a septate junction component, is required for a functional blood brain barrier.
Title: The IgLON protein Lachesin is required for the blood-brain barrier in Drosophila.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion involved in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in maintenance of epithelial integrity, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube size, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septate junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	HDA more info	PubMed
located_in septate junction	IDA Inferred from Direct Assay more info	PubMed

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain