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Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 363518, updated on 10-Oct-2024

Summary

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Official Symbol
Naa10provided by RGD
Official Full Name
N(alpha)-acetyltransferase 10, NatA catalytic subunitprovided by RGD
Primary source
RGD:1565315
See related
EnsemblRapid:ENSRNOG00000060063 AllianceGenome:RGD:1565315
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ard1; Ard1a; RGD1565315
Summary
Predicted to enable peptide-glutamate-N-acetyltransferase activity and peptide-serine-N-acetyltransferase activity. Predicted to contribute to peptide alpha-N-acetyltransferase activity and ribosome binding activity. Predicted to be involved in N-terminal peptidyl-glutamic acid acetylation; N-terminal peptidyl-serine acetylation; and negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric. Predicted to be located in cytosol and nucleolus. Predicted to be part of NatA complex. Human ortholog(s) of this gene implicated in Ogden syndrome and syndromic microphthalmia 1. Orthologous to human NAA10 (N-alpha-acetyltransferase 10, NatA catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 119.2), Spleen (RPKM 106.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Naa10 in Genome Data Viewer
Location:
Xq37
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156807378..156812632, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151656056..151661304, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156863655..156868950)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 4 Neighboring gene uncharacterized LOC120099366 Neighboring gene renin binding protein Neighboring gene host cell factor C1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Down-regulation of NAA10 mediates the neuroprotection induced by sevoflurane preconditioning via regulating ERK1/2 phosphorylation. Xu K, et al. Neurosci Lett, 2021 Jun 11. PMID 33872734
  2. Opposing Functions of the N-terminal Acetyltransferases Naa50 and NatA in Sister-chromatid Cohesion. Rong Z, et al. J Biol Chem, 2016 Sep 2. PMID 27422821, Free PMC Article
  3. Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. Myklebust LM, et al. Hum Mol Genet, 2015 Apr 1. PMID 25489052, Free PMC Article
  4. Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. Arnesen T, et al. Biochem J, 2005 Mar 15. PMID 15496142, Free PMC Article
  5. NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2. Yoon H, et al. Nat Commun, 2014 Nov 7. PMID 25376646

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Down-regulation of NAA10 mediates the neuroprotection induced by sevoflurane preconditioning via regulating ERK1/2 phosphorylation.
    Title: Down-regulation of NAA10 mediates the neuroprotection induced by sevoflurane preconditioning via regulating ERK1/2 phosphorylation.
  2. NAA10 acts as a guard ensuring balanced osteogenesis by fine-tuning Runx2 signalling in a feedback manner.
    Title: NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to peptide alpha-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide alpha-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide-glutamate-alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-serine-alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-terminal protein amino acid acetylation IEA
Inferred from Electronic Annotation
more info
  
involved_in N-terminal protein amino acid acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric ISO
Inferred from Sequence Orthology
more info
  
involved_in protein acetylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatA complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 10
Names
N-acetyltransferase ARD1 homolog
alpha-N-acetyltransferase 1A
NP_001129311.1
XP_006229653.1
XP_006229654.1
XP_017457606.1
XP_038955842.1
XP_038955843.1
XP_063136232.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135839.1 → NP_001129311.1  N-alpha-acetyltransferase 10

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    D3ZUQ2
    Related
    ENSRNOP00000074325.2, ENSRNOT00000083611.3
    Conserved Domains (2) summary
    COG0456
    Location:1 → 149
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:47 → 122
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    156807378..156812632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017602117.3 → XP_017457606.1  N-alpha-acetyltransferase 10 isoform X4

    UniProtKB/TrEMBL
    A6KRT6
    Conserved Domains (1) summary
    COG0456
    Location:1 → 149
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

  2. XM_006229592.5 → XP_006229654.1  N-alpha-acetyltransferase 10 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A9B2
    Related
    ENSRNOP00000089199.1, ENSRNOT00000116596.2
    Conserved Domains (2) summary
    COG0456
    Location:1 → 149
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:47 → 122
    Acetyltransf_1; Acetyltransferase (GNAT) family

  3. XM_006229591.5 → XP_006229653.1  N-alpha-acetyltransferase 10 isoform X1

    UniProtKB/TrEMBL
    D3ZUQ2
    Conserved Domains (2) summary
    COG0456
    Location:1 → 144
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:42 → 117
    Acetyltransf_1; Acetyltransferase (GNAT) family

  4. XM_063280162.1 → XP_063136232.1  N-alpha-acetyltransferase 10 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZXS8
    Related
    ENSRNOP00000083715.1, ENSRNOT00000109479.2

  5. XM_039099915.2 → XP_038955843.1  N-alpha-acetyltransferase 10 isoform X6

    UniProtKB/TrEMBL
    A6KRT5
    Conserved Domains (1) summary
    COG0456
    Location:1 → 122
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

  6. XM_039099914.2 → XP_038955842.1  N-alpha-acetyltransferase 10 isoform X5

    UniProtKB/TrEMBL
    A6KRT5
    Conserved Domains (1) summary
    COG0456
    Location:1 → 122
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version

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