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Cpr49Ae Cuticular protein 49Ae [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36351, updated on 2-Nov-2024

Summary

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Official Symbol
Cpr49Aeprovided by FlyBase
Official Full Name
Cuticular protein 49Aeprovided by FlyBase
Primary source
FLYBASE:FBgn0033728
Locus tag
Dmel_CG8505
See related
AllianceGenome:FB:FBgn0033728
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8505; DmelCpr49Ae; Dmel\CG8505
Summary
Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in several structures, including adult head; adult heart; embryonic head epidermis; embryonic salivary gland duct; and gut section. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Cpr49Ae in Genome Data Viewer
Location:
49A2-49A2; 2-67 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12402216..12405108)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8289721..8292613)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Odorant receptor 49a Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 49Af Neighboring gene Cuticular protein 49Ag

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila. Najarro MA, et al. PLoS Genet, 2015 Nov. PMID 26619284, Free PMC Article
  2. Drosophila DHR38 nuclear receptor is required for adult cuticle integrity at eclosion. Kozlova T, et al. Dev Dyn, 2009 Mar. PMID 19235727, Free PMC Article
  3. Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging. Kuintzle RC, et al. Nat Commun, 2017 Feb 21. PMID 28221375, Free PMC Article
  4. Drosophila P elements preferentially transpose to replication origins. Spradling AC, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21896744, Free PMC Article
  5. Label-free quantitative mass spectrometry analysis of the circadian proteome of Drosophila melanogaster lethal giant larvae mutants reveals potential therapeutic effects of melatonin. Wong KC, et al. Arch Insect Biochem Physiol, 2023 Jun. PMID 36915983

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of chitin-based larval cuticle IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of chitin-based larval cuticle ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in chitin-based cuticle development ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chitin-based extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chitin-based extracellular matrix ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
cuticular protein 49Ae
Names
CG8505-PA
Cpr49Ae-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12402216..12405108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136930.4 → NP_610774.3  cuticular protein 49Ae [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610774.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RB2, Q9V6B0
    Related
    FBpp0087031
    Conserved Domains (1) summary
    pfam00379
    Location:43 → 101
    Chitin_bind_4; Insect cuticle protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95RB2 Q95RB2

Gene LinkOut

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