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Mospd2 motile sperm domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363463, updated on 2-Nov-2024

Summary

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Official Symbol
Mospd2provided by RGD
Official Full Name
motile sperm domain containing 2provided by RGD
Primary source
RGD:1563952
See related
EnsemblRapid:ENSRNOG00000003350 AllianceGenome:RGD:1563952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563952
Summary
Predicted to enable FFAT motif binding activity. Predicted to be involved in lipid droplet formation; positive regulation of leukocyte chemotaxis; and protein homooligomerization. Predicted to be located in endoplasmic reticulum membrane; organelle membrane contact site; and plasma membrane. Predicted to be active in endomembrane system and endoplasmic reticulum-endosome membrane contact site. Orthologous to human MOSPD2 (motile sperm domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 111.8), Spleen (RPKM 105.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mospd2 in Genome Data Viewer
Location:
Xq14
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (33052063..33105550)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (29420485..29472099)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (31140967..31182823)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene RNA binding protein with serine rich domain 1 like 1 Neighboring gene FA complementation group B Neighboring gene thyroid hormone receptor associated protein 3, pseudogene 1 Neighboring gene U2 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of Motile Sperm Domain-Containing Protein 2 as Regulator of Human Monocyte Migration. Mendel I, et al. J Immunol, 2017 Mar 1. PMID 28137892, Free PMC Article
  2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables FFAT motif binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum-endosome membrane contact site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-endosome membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in organelle membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
motile sperm domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398727.1 → NP_001385656.1  motile sperm domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A0G2K8D1
    Related
    ENSRNOP00000074561.1, ENSRNOT00000084395.3
    Conserved Domains (2) summary
    pfam00635
    Location:327 → 431
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:93 → 234
    CRAL_TRIO; CRAL/TRIO domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    33052063..33105550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099873.2 → XP_038955801.1  motile sperm domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    D4A4X7
    Related
    ENSRNOP00000004494.7, ENSRNOT00000004494.7
    Conserved Domains (2) summary
    pfam00635
    Location:327 → 431
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:93 → 234
    CRAL_TRIO; CRAL/TRIO domain

  2. XM_006256866.5 → XP_006256928.1  motile sperm domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6K2K0
    Related
    ENSRNOP00000081484.2, ENSRNOT00000116700.2
    Conserved Domains (2) summary
    pfam00635
    Location:327 → 431
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:93 → 234
    CRAL_TRIO; CRAL/TRIO domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001134588.1: Suppressed sequence

    Description
    NM_001134588.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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