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Otud5 OTU deubiquitinase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363452, updated on 18-Sep-2024

Summary

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Official Symbol
Otud5provided by RGD
Official Full Name
OTU deubiquitinase 5provided by RGD
Primary source
RGD:1563027
See related
EnsemblRapid:ENSRNOG00000008764 AllianceGenome:RGD:1563027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable Lys48-specific deubiquitinase activity; Lys63-specific deubiquitinase activity; and thiol-dependent deubiquitinase. Predicted to be involved in several processes, including positive regulation of TOR signaling; protein deubiquitination; and response to lipopolysaccharide. Predicted to act upstream of or within several processes, including alpha-beta T cell differentiation; negative regulation of interleukin-17 production; and regulation of T-helper 17 type immune response. Orthologous to human OTUD5 (OTU deubiquitinase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 267.8), Spleen (RPKM 221.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Otud5 in Genome Data Viewer
Location:
Xq12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17296750..17331257, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14626173..14659331, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15471212..15504372, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member A2 Neighboring gene Pim-2 proto-oncogene, serine/threonine kinase Neighboring gene solute carrier family 25 member 39, pseudogene 6 Neighboring gene potassium voltage-gated channel subfamily D member 1 Neighboring gene GRIP1 associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphorylation-dependent activity of the deubiquitinase DUBA. Huang OW, et al. Nat Struct Mol Biol, 2012 Jan 15. PMID 22245969
  2. DUBA: a deubiquitinase that regulates type I interferon production. Kayagaki N, et al. Science, 2007 Dec 7. PMID 17991829
  3. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Rutz S, et al. Nature, 2015 Feb 19. PMID 25470037
  4. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Mevissen TE, et al. Cell, 2013 Jul 3. PMID 23827681, Free PMC Article
  5. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables K48-linked deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables K63-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables K63-linked deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within CD8-positive, alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within T-helper 17 cell lineage commitment ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
  
involved_in neural crest cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in neural crest cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in neural crest cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC2 signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TORC2 signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K63-linked deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of T-helper 17 type immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
OTU domain-containing protein 5
Names
DUBA
OTU domain containing 5
deubiquinating enzyme A
deubiquitinating enzyme A
NP_001032585.1
NP_001401659.1
XP_006256799.1
XP_006256802.1
XP_006256803.1
XP_063136188.1
XP_063136189.1
XP_063136190.1
XP_063136191.1
XP_063136192.1
XP_063136193.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037496.1 → NP_001032585.1  OTU domain-containing protein 5 isoform 2

    See identical proteins and their annotated locations for NP_001032585.1

    Status: PROVISIONAL

    Source sequence(s)
    BC110054
    UniProtKB/TrEMBL
    A6KP74
    Conserved Domains (1) summary
    cl19932
    Location:178 → 287
    OTU; OTU-like cysteine protease

  2. NM_001414730.1 → NP_001401659.1  OTU domain-containing protein 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    Q2YDU3
    UniProtKB/TrEMBL
    A6KP75

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    17296750..17331257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256737.5 → XP_006256799.1  OTU domain-containing protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AAB2, A6KP75
    Related
    ENSRNOP00000090218.1, ENSRNOT00000112857.2
    Conserved Domains (1) summary
    cl19932
    Location:294 → 403
    OTU; OTU-like cysteine protease

  2. XM_063280120.1 → XP_063136190.1  OTU domain-containing protein 5 isoform X4

    UniProtKB/TrEMBL
    A6KP74

  3. XM_006256741.5 → XP_006256803.1  OTU domain-containing protein 5 isoform X6

    UniProtKB/TrEMBL
    A0A0H2UHD0, A6KP74
    Related
    ENSRNOP00000006233.6, ENSRNOT00000006233.9
    Conserved Domains (1) summary
    cl19932
    Location:251 → 360
    OTU; OTU-like cysteine protease

  4. XM_006256740.5 → XP_006256802.1  OTU domain-containing protein 5 isoform X5

    UniProtKB/TrEMBL
    A6KP74
    Conserved Domains (1) summary
    cl19932
    Location:251 → 360
    OTU; OTU-like cysteine protease

  5. XM_063280121.1 → XP_063136191.1  OTU domain-containing protein 5 isoform X7

    UniProtKB/TrEMBL
    A6KP74

  6. XM_063280119.1 → XP_063136189.1  OTU domain-containing protein 5 isoform X3

    UniProtKB/TrEMBL
    A6KP74

  7. XM_063280118.1 → XP_063136188.1  OTU domain-containing protein 5 isoform X2

    UniProtKB/TrEMBL
    A6KP74

  8. XM_063280122.1 → XP_063136192.1  OTU domain-containing protein 5 isoform X8

  9. XM_063280123.1 → XP_063136193.1  OTU domain-containing protein 5 isoform X9

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2YDU3.2 GenPept UniProtKB/Swiss-Prot:Q2YDU3

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