U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sp100 SP100 nuclear antigen [ Rattus norvegicus (Norway rat) ]

Gene ID: 363269, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Symbol
Sp100provided by RGD
Full Name
SP100 nuclear antigenprovided by RGD
Primary source
RGD:1359550
See related
EnsemblRapid:ENSRNOG00000022769 AllianceGenome:RGD:1359550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; chromo shadow domain binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including innate immune response; regulation of signal transduction; and regulation of transcription, DNA-templated. Predicted to be located in cytoplasm and nuclear lumen. Predicted to be active in nucleus. Orthologous to human SP100 (SP100 nuclear antigen). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 236.2), Thymus (RPKM 138.4) and 8 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sp100 in Genome Data Viewer
Location:
9q35
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (93758975..93825068)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (86310990..86377036)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (92675103..92718489)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480599 Neighboring gene component of Sp100-rs Neighboring gene SP110 nuclear body protein Neighboring gene SP140 nuclear body protein Neighboring gene RIKEN cDNA A630001G21 gene like Neighboring gene uncharacterized LOC103690562

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex. Jiang WQ, et al. Mol Cell Biol, 2005 Apr. PMID 15767676, Free PMC Article
  2. Splice variants of the nuclear dot-associated Sp100 protein contain homologies to HMG-1 and a human nuclear phosphoprotein-box motif. Guldner HH, et al. J Cell Sci, 1999 Mar. PMID 9973607
  3. The interferon (IFN)-stimulated gene Sp100 promoter contains an IFN-gamma activation site and an imperfect IFN-stimulated response element which mediate type I IFN inducibility. Grötzinger T, et al. J Biol Chem, 1996 Oct 11. PMID 8810287
  4. Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis. Szostecki C, et al. J Immunol, 1990 Dec 15. PMID 2258622
  5. Differential role of Sp100 isoforms in interferon-mediated repression of herpes simplex virus type 1 immediate-early protein expression. Negorev DG, et al. J Virol, 2006 Aug. PMID 16873258, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables chromo shadow domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of protein location ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Fas signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cytokine ISO
Inferred from Sequence Orthology
more info
  
involved_in response to retinoic acid ISO
Inferred from Sequence Orthology
more info
  
involved_in response to type I interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Mre11 complex ISO
Inferred from Sequence Orthology
more info
  
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear periphery ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nuclear autoantigen Sp-100
Names
nuclear antigen Sp100
nuclear autoantigen Sp-100-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014220.1 → NP_001014242.1  nuclear autoantigen Sp-100 isoform 2

    See identical proteins and their annotated locations for NP_001014242.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083808
    UniProtKB/TrEMBL
    Q5XI80
    Conserved Domains (1) summary
    pfam03172
    Location:25 → 117
    Sp100; Sp100 domain

  2. NM_001401802.2 → NP_001388731.1  nuclear autoantigen Sp-100 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I5ZXL2
    Related
    ENSRNOP00000084228.1, ENSRNOT00000111514.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    93758975..93825068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083898.2 → XP_038939826.1  nuclear autoantigen Sp-100 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZXL2
    Conserved Domains (4) summary
    cd15626
    Location:588 → 629
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:483 → 558
    SAND; SAND domain
    pfam03172
    Location:23 → 119
    HSR; HSR domain
    cl02556
    Location:656 → 756
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  2. XM_039083903.2 → XP_038939831.1  nuclear autoantigen Sp-100 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZXL2
    Conserved Domains (4) summary
    cd15626
    Location:588 → 629
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:483 → 558
    SAND; SAND domain
    pfam03172
    Location:23 → 119
    HSR; HSR domain
    cl02556
    Location:656 → 732
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  3. XM_039083907.2 → XP_038939835.1  nuclear autoantigen Sp-100 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZXL2
    Conserved Domains (4) summary
    cd15626
    Location:588 → 629
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:483 → 558
    SAND; SAND domain
    pfam03172
    Location:23 → 119
    HSR; HSR domain
    cl02556
    Location:656 → 708
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  4. XM_039083911.2 → XP_038939839.1  nuclear autoantigen Sp-100 isoform X16

    UniProtKB/TrEMBL
    A0A8I5ZMP9
    Conserved Domains (3) summary
    cd15626
    Location:588 → 629
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:483 → 558
    SAND; SAND domain
    pfam03172
    Location:23 → 119
    HSR; HSR domain

  5. XM_039083913.2 → XP_038939841.1  nuclear autoantigen Sp-100 isoform X22

    UniProtKB/TrEMBL
    A0A8I5ZMP9
    Conserved Domains (3) summary
    cd15626
    Location:588 → 629
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:483 → 558
    SAND; SAND domain
    pfam03172
    Location:23 → 119
    HSR; HSR domain

  6. XM_039083914.2 → XP_038939842.1  nuclear autoantigen Sp-100 isoform X28

    UniProtKB/TrEMBL
    A0A8I5ZMP9
    Conserved Domains (2) summary
    pfam01342
    Location:483 → 558
    SAND; SAND domain
    pfam03172
    Location:23 → 119
    HSR; HSR domain

  7. XM_063267437.1 → XP_063123507.1  nuclear autoantigen Sp-100 isoform X29

    UniProtKB/TrEMBL
    A0A8I5ZMP9

  8. XM_039083900.2 → XP_038939828.1  nuclear autoantigen Sp-100 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZXL2
    Related
    ENSRNOP00000079517.2, ENSRNOT00000112510.2
    Conserved Domains (4) summary
    cd15626
    Location:565 → 606
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:460 → 535
    SAND; SAND domain
    pfam03172
    Location:23 → 119
    HSR; HSR domain
    cl02556
    Location:633 → 733
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  9. XM_063267424.1 → XP_063123494.1  nuclear autoantigen Sp-100 isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZXL2

  10. XM_039083905.2 → XP_038939833.1  nuclear autoantigen Sp-100 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZXL2
    Related
    ENSRNOP00000081917.2, ENSRNOT00000111279.2
    Conserved Domains (4) summary
    cd15626
    Location:548 → 589
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:443 → 518
    SAND; SAND domain
    pfam03172
    Location:23 → 119
    HSR; HSR domain
    cl02556
    Location:616 → 716
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  11. XM_039083902.2 → XP_038939830.1  nuclear autoantigen Sp-100 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZXL2
    Conserved Domains (4) summary
    cd15626
    Location:563 → 604
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:458 → 533
    SAND; SAND domain
    pfam03172
    Location:23 → 119
    HSR; HSR domain
    cl02556
    Location:631 → 731
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  12. XM_039083908.2 → XP_038939836.1  nuclear autoantigen Sp-100 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZXL2
    Conserved Domains (4) summary
    cd15626
    Location:540 → 581
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:435 → 510
    SAND; SAND domain
    pfam03172
    Location:23 → 119
    HSR; HSR domain
    cl02556
    Location:608 → 708
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  13. XM_039083910.2 → XP_038939838.1  nuclear autoantigen Sp-100 isoform X14

    UniProtKB/TrEMBL
    A0A8I5ZXL2
    Conserved Domains (4) summary
    cd15626
    Location:523 → 564
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:418 → 493
    SAND; SAND domain
    pfam03172
    Location:23 → 119
    HSR; HSR domain
    cl02556
    Location:591 → 691
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  14. XM_063267435.1 → XP_063123505.1  nuclear autoantigen Sp-100 isoform X26

    UniProtKB/TrEMBL
    A0A8I5ZMP9

  15. XM_063267423.1 → XP_063123493.1  nuclear autoantigen Sp-100 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZXL2

  16. XM_063267427.1 → XP_063123497.1  nuclear autoantigen Sp-100 isoform X15

    UniProtKB/TrEMBL
    A0A8I5ZXL2

  17. XM_039083899.2 → XP_038939827.1  nuclear autoantigen Sp-100 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZXL2, A0A8I6GKN6
    Related
    ENSRNOP00000093445.1, ENSRNOT00000110612.2
    Conserved Domains (4) summary
    cd15626
    Location:578 → 619
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:473 → 548
    SAND; SAND domain
    pfam03172
    Location:23 → 119
    HSR; HSR domain
    cl02556
    Location:646 → 746
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  18. XM_063267432.1 → XP_063123502.1  nuclear autoantigen Sp-100 isoform X23

    UniProtKB/TrEMBL
    A0A8I5ZPT8, A0A8I5ZXL2
    Related
    ENSRNOP00000080041.1, ENSRNOT00000095650.2

  19. XM_063267439.1 → XP_063123509.1  nuclear autoantigen Sp-100 isoform X31

    UniProtKB/TrEMBL
    A0A8I6G6P9

  20. XM_039083909.2 → XP_038939837.1  nuclear autoantigen Sp-100 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZXL2
    Conserved Domains (4) summary
    cd15626
    Location:538 → 579
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:433 → 508
    SAND; SAND domain
    pfam03172
    Location:23 → 119
    HSR; HSR domain
    cl02556
    Location:606 → 706
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  21. XM_063267440.1 → XP_063123510.1  nuclear autoantigen Sp-100 isoform X32

    UniProtKB/TrEMBL
    A0A0G2K6R2

  22. XM_063267426.1 → XP_063123496.1  nuclear autoantigen Sp-100 isoform X13

    UniProtKB/TrEMBL
    A0A8I5ZXL2
    Related
    ENSRNOP00000082712.2, ENSRNOT00000116342.2

  23. XM_063267428.1 → XP_063123498.1  nuclear autoantigen Sp-100 isoform X17

    UniProtKB/TrEMBL
    A0A8I5ZXL2
    Related
    ENSRNOP00000033655.8, ENSRNOT00000034152.8

  24. XM_063267425.1 → XP_063123495.1  nuclear autoantigen Sp-100 isoform X12

    UniProtKB/TrEMBL
    A0A8I5ZXL2

  25. XM_063267429.1 → XP_063123499.1  nuclear autoantigen Sp-100 isoform X19

    UniProtKB/TrEMBL
    A0A8I5ZXL2
    Related
    ENSRNOP00000073910.3, ENSRNOT00000080956.3

  26. XM_039083912.2 → XP_038939840.1  nuclear autoantigen Sp-100 isoform X18

    UniProtKB/TrEMBL
    A0A8I5ZXL2
    Conserved Domains (4) summary
    cd15626
    Location:513 → 554
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:408 → 483
    SAND; SAND domain
    pfam03172
    Location:23 → 119
    HSR; HSR domain
    cl02556
    Location:581 → 681
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  27. XM_063267431.1 → XP_063123501.1  nuclear autoantigen Sp-100 isoform X21

    UniProtKB/TrEMBL
    A0A8I5ZXL2

  28. XM_063267430.1 → XP_063123500.1  nuclear autoantigen Sp-100 isoform X20

    UniProtKB/TrEMBL
    A0A8I5ZXL2
    Related
    ENSRNOP00000097798.2, ENSRNOT00000102336.2

  29. XM_063267433.1 → XP_063123503.1  nuclear autoantigen Sp-100 isoform X24

    UniProtKB/TrEMBL
    A0A8I5ZXL2, A0A8I6ATB4

  30. XM_063267438.1 → XP_063123508.1  nuclear autoantigen Sp-100 isoform X30

    UniProtKB/TrEMBL
    A0A8I6G6P9

  31. XM_063267441.1 → XP_063123511.1  nuclear autoantigen Sp-100 isoform X33

    UniProtKB/TrEMBL
    A0A0G2K6R2

  32. XM_063267434.1 → XP_063123504.1  nuclear autoantigen Sp-100 isoform X25

    UniProtKB/TrEMBL
    A0A8I5ZXL2

  33. XM_063267436.1 → XP_063123506.1  nuclear autoantigen Sp-100 isoform X27

    UniProtKB/TrEMBL
    A0A8I5ZXL2

  34. XM_063267442.1 → XP_063123512.1  nuclear autoantigen Sp-100 isoform X34

  35. XM_039083915.2 → XP_038939843.1  nuclear autoantigen Sp-100 isoform X35

    Conserved Domains (1) summary
    pfam03172
    Location:23 → 119
    HSR; HSR domain

  36. XM_006245338.5 → XP_006245400.2  nuclear autoantigen Sp-100 isoform X36

    UniProtKB/TrEMBL
    F7FPF5
    Conserved Domains (1) summary
    pfam03172
    Location:23 → 119
    HSR; HSR domain

RNA

  1. XR_005488939.2 RNA Sequence

  2. XR_010054616.1 RNA Sequence

  3. XR_010054615.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials