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Cyb561d2 cytochrome b561 family, member D2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363137, updated on 4-Jan-2025

Summary

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Official Symbol
Cyb561d2provided by RGD
Official Full Name
cytochrome b561 family, member D2provided by RGD
Primary source
RGD:1359644
See related
EnsemblRapid:ENSRNOG00000021887 AllianceGenome:RGD:1359644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable heme binding activity; transmembrane ascorbate ferrireductase activity; and transmembrane monodehydroascorbate reductase activity. Predicted to be involved in ascorbate homeostasis. Predicted to be located in vesicle. Predicted to be active in endoplasmic reticulum. Orthologous to human CYB561D2 (cytochrome b561 family member D2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 65.8), Brain (RPKM 61.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cyb561d2 in Genome Data Viewer
Location:
8q32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117091844..117094434, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108213201..108215778, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116295328..116297879, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 2 Neighboring gene uncharacterized LOC120094259 Neighboring gene transmembrane protein 115 Neighboring gene NPR2-like, GATOR1 complex subunit Neighboring gene zinc finger, MYND-type containing 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Spectral characterization of the recombinant mouse tumor suppressor 101F6 protein. Bérczi A, et al. Eur Biophys J, 2010 Jul. PMID 19943161
  2. Involvement of 101F6, a homologue of cytochrome b561, in the reduction of ferric ions. Mizutani A, et al. J Biochem, 2007 Dec. PMID 17938141
  3. Functional expression and characterization of human 101F6 protein, a homologue of cytochrome b561 and a candidate tumor suppressor gene product. Recuenco MC, et al. Biofactors, 2008. PMID 19734123
  4. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. Lerman MI, et al. Cancer Res, 2000 Nov 1. PMID 11085536
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC95239

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables heme binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane ascorbate ferrireductase activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane ascorbate ferrireductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane monodehydroascorbate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane monodehydroascorbate reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane monodehydroascorbate reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ascorbate homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in ascorbate homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transmembrane reductase CYB561D2
Names
cytochrome b-561 domain containing 2
cytochrome b561 domain-containing protein 2
putative tumor suppressor protein 101F6
transmembrane ascorbate ferrireductase
NP_001007754.1
XP_006243866.1
XP_038937724.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007753.2 → NP_001007754.1  transmembrane reductase CYB561D2

    See identical proteins and their annotated locations for NP_001007754.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q641Y1
    UniProtKB/TrEMBL
    A0A8L2QHT3, A6I2X3
    Related
    ENSRNOP00000071082.1, ENSRNOT00000082320.3
    Conserved Domains (1) summary
    cd08761
    Location:25 → 205
    Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product

  2. NM_001434351.1 → NP_001421280.1  transmembrane reductase CYB561D2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q641Y1
    UniProtKB/TrEMBL
    A0A8L2QHT3, A6I2X3

  3. NM_001434352.1 → NP_001421281.1  transmembrane reductase CYB561D2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q641Y1
    UniProtKB/TrEMBL
    A0A8L2QHT3, A6I2X3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    117091844..117094434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243804.5 → XP_006243866.1  transmembrane reductase CYB561D2 isoform X1

    Conserved Domains (1) summary
    cd08761
    Location:25 → 205
    Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product

  2. XM_039081796.2 → XP_038937724.1  transmembrane reductase CYB561D2 isoform X1

    Conserved Domains (1) summary
    cd08761
    Location:25 → 205
    Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q641Y1.1 GenPept UniProtKB/Swiss-Prot:Q641Y1

Gene LinkOut

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