U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363131, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Pik3r4provided by RGD
Official Full Name
phosphoinositide-3-kinase, regulatory subunit 4provided by RGD
Primary source
RGD:1311809
See related
EnsemblRapid:ENSRNOG00000013669 AllianceGenome:RGD:1311809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to glucose starvation; late endosome to vacuole transport; and positive regulation of phosphatidylinositol 3-kinase activity. Predicted to be located in axoneme; intracellular membrane-bounded organelle; and microtubule cytoskeleton. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in late endosome and nucleus-vacuole junction. Orthologous to human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 90.4), Adrenal (RPKM 82.1) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pik3r4 in Genome Data Viewer
Location:
8q32
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115146660..115195326)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (106267908..106316585)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (114300248..114350686)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29, pseudogene 14 Neighboring gene 5S ribosomal RNA Neighboring gene ribosomal protein L29 Neighboring gene collagen type VI alpha 6 chain Neighboring gene uncharacterized LOC103693167 Neighboring gene collagen type VI alpha 5 chain

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Human VPS34 and p150 are Rab7 interacting partners. Stein MP, et al. Traffic, 2003 Nov. PMID 14617358
  2. The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression. Sun Q, et al. J Biol Chem, 2011 Jan 7. PMID 21062745, Free PMC Article
  3. A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. Thoresen SB, et al. Exp Cell Res, 2010 Dec 10. PMID 20643123
  4. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Kim J, et al. Cell, 2013 Jan 17. PMID 23332761, Free PMC Article
  5. Mammalian autophagy: core molecular machinery and signaling regulation. Yang Z, et al. Curr Opin Cell Biol, 2010 Apr. PMID 20034776, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in late endosome to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in late endosome to vacuole transport IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in pexophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol-3-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus-vacuole junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex, class III ISO
Inferred from Sequence Orthology
more info
  
part_of phosphatidylinositol 3-kinase complex, class III ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of phosphatidylinositol 3-kinase complex, class III, type I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex, class III, type II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
phosphoinositide 3-kinase regulatory subunit 4
Names
PI3-kinase regulatory subunit 4
phosphoinositide-3-kinase, regulatory subunit 4, p150
NP_001388143.1
XP_006243863.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401214.1 → NP_001388143.1  phosphoinositide 3-kinase regulatory subunit 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    P0C0R5
    UniProtKB/TrEMBL
    B5DFA2
    Related
    ENSRNOP00000018654.4, ENSRNOT00000018654.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    115146660..115195326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243801.5 → XP_006243863.1  phosphoinositide 3-kinase regulatory subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_006243863.1

    UniProtKB/Swiss-Prot
    P0C0R5
    UniProtKB/TrEMBL
    A6I2N5, B5DFA2
    Conserved Domains (8) summary
    smart00320
    Location:1327 → 1358
    WD40; WD40 repeats
    COG2319
    Location:991 → 1358
    WD40; WD40 repeat [General function prediction only]
    cd13980
    Location:25 → 320
    STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
    pfam00069
    Location:26 → 309
    Pkinase; Protein kinase domain
    pfam07539
    Location:352 → 449
    DRIM; Down-regulated in metastasis
    sd00044
    Location:539 → 566
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:997 → 1040
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:985 → 1269
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108777.1: Suppressed sequence

    Description
    NM_001108777.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C0R5.2 GenPept UniProtKB/Swiss-Prot:P0C0R5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous