Prp8 pre-mRNA processing factor 8 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Prp8provided by FlyBase
Official Full Name: pre-mRNA processing factor 8provided by FlyBase
Primary source: FLYBASE:FBgn0033688
Locus tag: Dmel_CG8877
See related: AllianceGenome:FB:FBgn0033688
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A1Z8U0; CG8877; Dmel\CG8877; E-2e; prp8
Summary: Predicted to enable pre-mRNA intronic binding activity and snRNA binding activity. Involved in mRNA splicing, via spliceosome and spermatogenesis. Located in cytoplasm. Part of small nuclear ribonucleoprotein complex. Is expressed in adult head. Used to study retinitis pigmentosa 13. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 13. Orthologous to human PRPF8 (pre-mRNA processing factor 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12154258..12162998, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (8041763..8050503, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8.
Title: A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8.
Ecd promotes U5 snRNP maturation and Prp8 stability.
Title: Ecd promotes U5 snRNP maturation and Prp8 stability.
Precursor RNA processing 3 is required for male fertility, and germline stem cell self-renewal and differentiation via regulating spliceosome function in Drosophila testes.
Title: Precursor RNA processing 3 is required for male fertility, and germline stem cell self-renewal and differentiation via regulating spliceosome function in Drosophila testes.
Prp8 regulates hyperplasia.
Title: Prp8 regulates oncogene-induced hyperplastic growth in Drosophila.
brr2 and Prp8 play crucial roles in controlling the expression of the FMRFa neuropeptide specifically in six neurons of the VNC (Tv4 neurons).
Title: Specification of Drosophila neuropeptidergic neurons by the splicing component brr2.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables U1 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U2 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U5 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U5 snRNA binding	IEA Inferred from Electronic Annotation more info
enables U6 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U6 snRNA binding	IEA Inferred from Electronic Annotation more info
NOT enables metal-dependent deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables pre-mRNA intronic binding	IBA Inferred from Biological aspect of Ancestor more info
enables snRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spliceosomal tri-snRNP complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ventral cord development	HMP more info	PubMed

Component	Evidence Code	Pubs
part_of U5 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U5 snRNP	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of catalytic step 2 spliceosome	HDA more info	PubMed
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed
part_of small nuclear ribonucleoprotein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

Names: CG8877-PA; Prp8-PA; U5 small nuclear ribonucleoprotein-specific factor; prp8

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