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Smyd4-4 SET and MYND domain containing, class 4, member 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36299, updated on 28-Oct-2024

Summary

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Official Symbol
Smyd4-4provided by FlyBase
Official Full Name
SET and MYND domain containing, class 4, member 4provided by FlyBase
Primary source
FLYBASE:FBgn0027495
Locus tag
Dmel_CG8378
See related
AllianceGenome:FB:FBgn0027495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD29892; CG8378; Dmel\CG8378
Summary
Predicted to enable histone H3K4 methyltransferase activity and histone deacetylase binding activity. Involved in compound eye photoreceptor development. Located in cytoplasm and nucleus. Is expressed in embryonic/larval gut; larval central nervous system; larval somatic muscle cell; midgut primordium; and procephalic segment. Orthologous to human SMYD4 (SET and MYND domain containing 4). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See Smyd4-4 in Genome Data Viewer
Location:
48E2-48E2; 2-66 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12140631..12143272)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8028136..8030777)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene jelly belly Neighboring gene uncharacterized protein Neighboring gene SKP1-related B Neighboring gene Organic solute carrier partner 1 Neighboring gene Hen1 methyltransferase Neighboring gene back seat driver Neighboring gene uncharacterized protein Neighboring gene pre-mRNA processing factor 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionary History of the Smyd Gene Family in Metazoans: A Framework to Identify the Orthologs of Human Smyd Genes in Drosophila and Other Animal Species. Calpena E, et al. PLoS One, 2015. PMID 26230726, Free PMC Article
  2. A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development. Thompson EC, et al. PLoS One, 2008 Aug 20. PMID 18714374, Free PMC Article
  3. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected]. Palumbo V, et al. Curr Biol, 2015 Jun 29. PMID 26096973, Free PMC Article
  4. Comparative genomic analysis of SET domain family reveals the origin, expansion, and putative function of the arthropod-specific SmydA genes as histone modifiers in insects. Jiang F, et al. Gigascience, 2017 Jun 1. PMID 28444351, Free PMC Article
  5. Genome-wide patterns of local adaptation in Western European Drosophila melanogaster natural populations. Mateo L, et al. Sci Rep, 2018 Nov 1. PMID 30385770, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone H3K4 methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone deacetylase binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in compound eye photoreceptor development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SET and MYND domain containing, class 4, member 4
Names
CG8378-PA
Smyd4-4-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12140631..12143272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136886.3 → NP_610730.1  SET and MYND domain containing, class 4, member 4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610730.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L0CP31, Q7KMH5
    Related
    FBpp0087091
    Conserved Domains (3) summary
    pfam00856
    Location:363 → 463
    SET; SET domain
    pfam01753
    Location:230 → 270
    zf-MYND; MYND finger
    pfam13414
    Location:67 → 138
    TPR_11; TPR repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KMH5 Q7KMH5

Gene LinkOut

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