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Trmu tRNA mitochondrial 2-thiouridylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 362976, updated on 17-Aug-2024

Summary

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Official Symbol
Trmuprovided by RGD
Official Full Name
tRNA mitochondrial 2-thiouridylaseprovided by RGD
Primary source
RGD:1311229
See related
EnsemblRapid:ENSRNOG00000016465 AllianceGenome:RGD:1311229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mtu1
Summary
Predicted to enable several functions, including ATP binding activity; tRNA binding activity; and tRNA-5-taurinomethyluridine 2-sulfurtransferase. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in aminoglycoside-induced deafness; infantile liver failure syndrome; and transient infantile liver failure. Orthologous to human TRMU (tRNA mitochondrial 2-thiouridylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 76.9), Adrenal (RPKM 67.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trmu in Genome Data Viewer
Location:
7q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (118849586..118866190)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (116969750..116987704)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (126756140..126772749)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 38 Neighboring gene G-2 and S-phase expressed 1 Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 1 Neighboring gene GRAM domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mitochondrial Infantile Liver Disease due to TRMU Gene Mutations: Three New Cases. Gaignard P, et al. JIMD Rep, 2013. PMID 23625533, Free PMC Article
  2. Acute infantile liver failure due to mutations in the TRMU gene. Zeharia A, et al. Am J Hum Genet, 2009 Sep. PMID 19732863, Free PMC Article
  3. Identification and characterization of mouse TRMU gene encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase. Yan Q, et al. Biochim Biophys Acta, 2004 Jan 20. PMID 14746906
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-5-taurinomethyluridine 2-sulfurtransferase IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble position uridine thiolation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial tRNA-specific 2-thiouridylase 1
Names
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase 1
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
NP_001129348.1
NP_001388104.1
XP_038935542.1
XP_063120014.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135876.1 → NP_001129348.1  mitochondrial tRNA-specific 2-thiouridylase 1 isoform 1

    See identical proteins and their annotated locations for NP_001129348.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HTF7, D3ZLU4
    Related
    ENSRNOP00000022511.5, ENSRNOT00000022511.8
    Conserved Domains (2) summary
    cd01998
    Location:6 → 383
    tRNA_Me_trans; tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs. ...
    pfam03054
    Location:5 → 383
    tRNA_Me_trans; tRNA methyl transferase

  2. NM_001401175.1 → NP_001388104.1  mitochondrial tRNA-specific 2-thiouridylase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    B1WC37
    Related
    ENSRNOP00000061254.1, ENSRNOT00000065283.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    118849586..118866190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079614.2 → XP_038935542.1  mitochondrial tRNA-specific 2-thiouridylase 1 isoform X1

    Conserved Domains (1) summary
    pfam03054
    Location:5 → 293
    tRNA_Me_trans; tRNA methyl transferase

  2. XM_063263944.1 → XP_063120014.1  mitochondrial tRNA-specific 2-thiouridylase 1 isoform X2

RNA

  1. XR_005486683.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1WC37.1 GenPept UniProtKB/Swiss-Prot:B1WC37

Gene LinkOut

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