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Dazap1 DAZ associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362836, updated on 17-Aug-2024

Summary

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Official Symbol
Dazap1provided by RGD
Official Full Name
DAZ associated protein 1provided by RGD
Primary source
RGD:1305280
See related
EnsemblRapid:ENSRNOG00000031387 AllianceGenome:RGD:1305280
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of mRNA splicing, via spliceosome and spermatogenesis. Predicted to act upstream of or within cell population proliferation and maternal placenta development. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Orthologous to human DAZAP1 (DAZ associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 133.0), Testes (RPKM 110.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dazap1 in Genome Data Viewer
Location:
7q11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10074342..10098810, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9423673..9448116, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12289895..12315897, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 19 open reading frame 25 Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene ribosomal protein S15 Neighboring gene guanidinoacetate N-methyltransferase Neighboring gene NADH:ubiquinone oxidoreductase core subunit S7 Neighboring gene transfer RNA asparagine (anticodon GUU) 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice. Hsu LC, et al. RNA, 2008 Sep. PMID 18669443, Free PMC Article
  2. Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries. Pan HA, et al. Fertil Steril, 2005 Oct. PMID 16209998
  3. Dynamic changes in intranuclear and subcellular localizations of mouse Prrp/DAZAP1 during spermatogenesis: the necessity of the C-terminal proline-rich region for nuclear import and localization. Kurihara Y, et al. Arch Histol Cytol, 2004 Nov. PMID 15700540
  4. The RNA ligands for mouse proline-rich RNA-binding protein (mouse Prrp) contain two consensus sequences in separate loop structure. Hori T, et al. Nucleic Acids Res, 2005. PMID 15647502, Free PMC Article
  5. Deleted in azoospermia associated protein 1 shuttles between nucleus and cytoplasm during normal germ cell maturation. Vera Y, et al. J Androl, 2002 Sep-Oct. PMID 12185095

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC114376

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA stem-loop binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(G) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(G) binding ISO
Inferred from Sequence Orthology
more info
  
enables poly(U) RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within maternal placenta development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DAZ-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025742.1 → NP_001020913.1  DAZ-associated protein 1

    See identical proteins and their annotated locations for NP_001020913.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098930
    UniProtKB/TrEMBL
    A0A8I6A8F6, F2Z3S1, Q4KLZ3
    Related
    ENSRNOP00000090669.2, ENSRNOT00000100123.2
    Conserved Domains (2) summary
    cd12327
    Location:110 → 189
    RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    cd12574
    Location:11 → 92
    RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10074342..10098810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240970.5 → XP_006241032.1  DAZ-associated protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006241032.1

    UniProtKB/TrEMBL
    A0A8I6A8F6, A6K8N1
    Conserved Domains (2) summary
    cd12327
    Location:102 → 181
    RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    cd12574
    Location:3 → 84
    RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

  2. XM_006240969.5 → XP_006241031.1  DAZ-associated protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006241031.1

    UniProtKB/TrEMBL
    A0A8I6A8F6, A0A8I6ANV1
    Conserved Domains (2) summary
    cd12327
    Location:103 → 182
    RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    cd12574
    Location:3 → 84
    RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

  3. XM_039079402.2 → XP_038935330.1  DAZ-associated protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A8F6
    Conserved Domains (2) summary
    cd12327
    Location:111 → 190
    RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    cd12574
    Location:11 → 92
    RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

  4. XM_063263744.1 → XP_063119814.1  DAZ-associated protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A8F6

  5. XM_006240968.5 → XP_006241030.1  DAZ-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006241030.1

    UniProtKB/TrEMBL
    A0A8I6A8F6, A0A8J8XF56
    Related
    ENSRNOP00000046032.5, ENSRNOT00000046886.6
    Conserved Domains (2) summary
    cd12327
    Location:111 → 190
    RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    cd12574
    Location:11 → 92
    RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

  6. XM_063263745.1 → XP_063119815.1  DAZ-associated protein 1 isoform X6

Nucleotide Protein Strain
Heading Accession and Version

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