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Coq10a coenzyme Q10A [ Rattus norvegicus (Norway rat) ]

Gene ID: 362810, updated on 28-Oct-2024

Summary

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Official Symbol
Coq10aprovided by RGD
Official Full Name
coenzyme Q10Aprovided by RGD
Primary source
RGD:1562447
See related
EnsemblRapid:ENSRNOG00000029571 AllianceGenome:RGD:1562447
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562447
Summary
Predicted to enable ubiquinone binding activity. Predicted to be involved in cellular respiration. Predicted to be active in mitochondrion. Orthologous to human COQ10A (coenzyme Q10A). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Muscle (RPKM 417.9), Heart (RPKM 194.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Coq10a in Genome Data Viewer
Location:
7q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1376591..1387694, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (792089..798392, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2780930..2788189, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene canopy FGF signaling regulator 2 Neighboring gene citrate synthase Neighboring gene ankyrin repeat domain 52 Neighboring gene solute carrier family 39 member 5 Neighboring gene small nucleolar RNA SNORA79 Neighboring gene nucleic acid binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Modulatory effect of exogenous Coenzyme Q(10) on redox and inflammatory biomarkers during aging in rats. Srivastava P, et al. Biol Futur, 2022 Dec. PMID 36443592
  2. Coenzyme Q10 protects renal proximal tubule cells against nicotine-induced apoptosis through induction of p66(shc)-dependent antioxidant responses. Arany I, et al. Apoptosis, 2017 Feb. PMID 27770269
  3. Simvastatin decreased coenzyme Q in the left ventricle and skeletal muscle but not in the brain and liver in L-NAME-induced hypertension. Kucharská J, et al. Physiol Res, 2007. PMID 17824807
  4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Modulatory effect of exogenous Coenzyme Q10 on redox and inflammatory biomarkers during aging in rats.
    Title: Modulatory effect of exogenous Coenzyme Q(10) on redox and inflammatory biomarkers during aging in rats.
  2. Our studies revealed that Coenzyme Q10 strongly inhibits nicotine-mediated production of reactive oxygen species and consequent apoptosis that requires serine36 phosphorylation but not mitochondrial translocation/cytochrome c binding of p66(shc).
    Title: Coenzyme Q10 protects renal proximal tubule cells against nicotine-induced apoptosis through induction of p66(shc)-dependent antioxidant responses.
  3. Administration of simvastatin under the condition of nitric oxide-deficiency reduced the level of coenzyme Q9/10 in the heart and skeletal muscle.
    Title: Simvastatin decreased coenzyme Q in the left ventricle and skeletal muscle but not in the brain and liver in L-NAME-induced hypertension.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquinone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular respiration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
coenzyme Q-binding protein COQ10 homolog A, mitochondrial
Names
coenzyme Q10 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108727.1 → NP_001102197.1  coenzyme Q-binding protein COQ10 homolog A, mitochondrial

    See identical proteins and their annotated locations for NP_001102197.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474104
    UniProtKB/TrEMBL
    A6KSC6, D3ZX74
    Related
    ENSRNOP00000044290.3, ENSRNOT00000047530.6
    Conserved Domains (1) summary
    cd07813
    Location:57 → 195
    COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    1376591..1387694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240759.5 → XP_006240821.1  coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006240821.1

    UniProtKB/TrEMBL
    A6KSC5
    Conserved Domains (1) summary
    cd07813
    Location:89 → 227
    COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins

  2. XM_039079365.2 → XP_038935293.1  coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A0G2JYY6
    Related
    ENSRNOP00000070841.2, ENSRNOT00000086939.3
    Conserved Domains (1) summary
    cd07813
    Location:89 → 237
    COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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