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exp expansion [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36276, updated on 2-Nov-2024

Summary

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Official Symbol
expprovided by FlyBase
Official Full Name
expansionprovided by FlyBase
Primary source
FLYBASE:FBgn0033668
Locus tag
Dmel_CG13188
See related
AllianceGenome:FB:FBgn0033668
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13188; Dmel\CG13188; Exp
Summary
Involved in chitin-based embryonic cuticle biosynthetic process and trachea morphogenesis. Located in apical part of cell and cytoplasm. Is active in cytoplasmic side of apical plasma membrane. Is expressed in several structures, including embryonic head epidermis; embryonic ventral epidermis; epithelium; larval tracheal system; and tracheal dorsal trunk primordium. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See exp in Genome Data Viewer
Location:
48D3-48D5; 2-65 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11939557..11967435)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7827062..7854940)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44305 Neighboring gene long non-coding RNA:CR44312 Neighboring gene Proteasome inhibitor 31 kDa Neighboring gene ADD domain-containing protein 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deciphering the genetic programme triggering timely and spatially-regulated chitin deposition. Moussian B, et al. PLoS Genet, 2015 Jan. PMID 25617778, Free PMC Article
  2. Structure of the N-terminal domain of the protein Expansion: an 'Expansion' to the Smad MH2 fold. Beich-Frandsen M, et al. Acta Crystallogr D Biol Crystallogr, 2015 Apr. PMID 25849395, Free PMC Article
  3. A dynamic interplay between chitin synthase and the proteins Expansion/Rebuf reveals that chitin polymerisation and translocation are uncoupled in Drosophila. De Giorgio E, et al. PLoS Biol, 2023 Jan. PMID 36689563, Free PMC Article
  4. The novel Smad protein Expansion regulates the receptor tyrosine kinase pathway to control Drosophila tracheal tube size. Iordanou E, et al. Dev Biol, 2014 Sep 1. PMID 24973580, Free PMC Article
  5. DDT resistance in Drosophila correlates with Cyp6g1 over-expression and confers cross-resistance to the neonicotinoid imidacloprid. Daborn P, et al. Mol Genet Genomics, 2001 Dec. PMID 11810226

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A dynamic interplay between chitin synthase and the proteins Expansion/Rebuf reveals that chitin polymerisation and translocation are uncoupled in Drosophila.
    Title: A dynamic interplay between chitin synthase and the proteins Expansion/Rebuf reveals that chitin polymerisation and translocation are uncoupled in Drosophila.
  2. To compare the Expansion and Smad MH2 domains, the crystal structure of the Expansion domain was determined at 1.6 A resolution, the first structure of a non-Smad MH2 domain to be characterized to date.
    Title: Structure of the N-terminal domain of the protein Expansion: an 'Expansion' to the Smad MH2 fold.
  3. This work provides a clear understanding of the role of Expansion, anovel Smad protein, in the regulation of Drosophila tracheal tube diameter.
    Title: The novel Smad protein Expansion regulates the receptor tyrosine kinase pathway to control Drosophila tracheal tube size.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in chitin-based embryonic cuticle biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in trachea morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic side of apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
expansion
Names
CG13188-PA
CG13188-PB
exp-PA
exp-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11939557..11967435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165853.2 → NP_725091.1  expansion, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725091.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z8R1
    Related
    FBpp0087145
    Conserved Domains (1) summary
    cl00056
    Location:56 → 224
    MH2; C-terminal Mad Homology 2 (MH2) domain

  2. NM_136870.2 → NP_610714.1  expansion, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610714.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z8R0, Q7YU38
    Related
    FBpp0087146
    Conserved Domains (1) summary
    cl00056
    Location:56 → 224
    MH2; C-terminal Mad Homology 2 (MH2) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z8R0 A1Z8R0
A1Z8R1 A1Z8R1
Q7YU38 Q7YU38

Gene LinkOut

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