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Hectd1 HECT domain E3 ubiquitin protein ligase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362736, updated on 18-Sep-2024

Summary

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Official Symbol
Hectd1provided by RGD
Official Full Name
HECT domain E3 ubiquitin protein ligase 1provided by RGD
Primary source
RGD:1561653
See related
EnsemblRapid:ENSRNOG00000006905 AllianceGenome:RGD:1561653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561653
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in anatomical structure development and protein K63-linked ubiquitination. Predicted to act upstream of or within several processes, including animal organ development; negative regulation of protein localization to plasma membrane; and protein autoubiquitination. Orthologous to human HECTD1 (HECT domain E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 596.9), Heart (RPKM 507.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hectd1 in Genome Data Viewer
Location:
6q23
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (74916803..75003408, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (69181429..69268045, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (72509658..72596285, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene cochlin Neighboring gene striatin 3 Neighboring gene adaptor related protein complex 4 subunit sigma 1 Neighboring gene uncharacterized LOC120103536 Neighboring gene uncharacterized LOC134479181 Neighboring gene HEAT repeat containing 5A Neighboring gene uncharacterized LOC134479124 Neighboring gene D-aminoacyl-tRNA deacylase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme. Sarkar AA, et al. J Cell Biol, 2012 Mar 19. PMID 22431752, Free PMC Article
  2. The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure. Zohn IE, et al. Dev Biol, 2007 Jun 1. PMID 17442300, Free PMC Article
  3. Hectd1 is required for development of the junctional zone of the placenta. Sarkar AA, et al. Dev Biol, 2014 Aug 15. PMID 24855001, Free PMC Article
  4. A phenotype-based screen for embryonic lethal mutations in the mouse. Kasarskis A, et al. Proc Natl Acad Sci U S A, 1998 Jun 23. PMID 9636176, Free PMC Article
  5. Analysis of mouse embryonic patterning and morphogenesis by forward genetics. García-García MJ, et al. Proc Natl Acad Sci U S A, 2005 Apr 26. PMID 15755804, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircHECTD1 promoted MIRI-associated inflammation via inhibiting miR-138-5p and upregulating ROCK2.
    Title: CircHECTD1 promoted MIRI-associated inflammation via inhibiting miR-138-5p and upregulating ROCK2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aorta development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic placenta development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart valve development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within natural killer cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
  
involved_in neural tube closure ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spongiotrophoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within trophoblast giant cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ventricular septum development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HECTD1
Names
HECT domain containing 1
HECT domain containing E3 ubiquitin protein ligase 1
NP_001406767.1
NP_001406768.1
NP_001406769.1
XP_006240149.1
XP_038969108.1
XP_063118174.1
XP_063118175.1
XP_063118176.1
XP_063118177.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419838.1 → NP_001406767.1  E3 ubiquitin-protein ligase HECTD1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    D3ZLS5
    Related
    ENSRNOP00000008459.7, ENSRNOT00000008459.9

  2. NM_001419839.1 → NP_001406768.1  E3 ubiquitin-protein ligase HECTD1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  3. NM_001419840.1 → NP_001406769.1  E3 ubiquitin-protein ligase HECTD1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I5ZNU0
    Related
    ENSRNOP00000079874.1, ENSRNOT00000108705.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    74916803..75003408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262104.1 → XP_063118174.1  E3 ubiquitin-protein ligase HECTD1 isoform X3

  2. XM_039113180.2 → XP_038969108.1  E3 ubiquitin-protein ligase HECTD1 isoform X1

    Conserved Domains (6) summary
    cd00078
    Location:2130 → 2607
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:1276 → 1334
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:1106 → 1239
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    pfam18410
    Location:1891 → 1964
    BTHB; Basic tilted helix bundle domain

  3. XM_063262105.1 → XP_063118175.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

  4. XM_063262107.1 → XP_063118177.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

  5. XM_063262106.1 → XP_063118176.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

  6. XM_006240087.4 → XP_006240149.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

    Conserved Domains (7) summary
    smart00119
    Location:2153 → 2605
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:2129 → 2606
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06701
    Location:1277 → 1335
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    cl23730
    Location:1107 → 1240
    F5_F8_type_C; F5/8 type C domain
Nucleotide Protein Strain
Heading Accession and Version

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