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Camta1 calmodulin binding transcription activator 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362665, updated on 2-Nov-2024

Summary

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Symbol
Camta1provided by RGD
Full Name
calmodulin binding transcription activator 1provided by RGD
Primary source
RGD:1562703
See related
EnsemblRapid:ENSRNOG00000018602 AllianceGenome:RGD:1562703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in positive regulation of calcineurin-NFAT signaling cascade and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within neuromuscular process controlling balance. Predicted to be located in cytosol and nucleolus. Human ortholog(s) of this gene implicated in nonprogressive cerebellar ataxia with mental retardation. Orthologous to human CAMTA1 (calmodulin binding transcription activator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 141.2), Heart (RPKM 49.5) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Camta1 in Genome Data Viewer
Location:
5q36
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (166791639..167639502, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (161510283..162356902, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (168138207..169017295, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487044 Neighboring gene period circadian regulator 3 Neighboring gene vesicle-associated membrane protein 3 Neighboring gene uncharacterized LOC134487045 Neighboring gene uncharacterized LOC134487043 Neighboring gene uncharacterized LOC120103136 Neighboring gene uncharacterized LOC120103137 Neighboring gene ribosomal protein S7, pseudogene 23 Neighboring gene DnaJ heat shock protein family (Hsp40) member C11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Integrator of Stress Responses Calmodulin Binding Transcription Activator 1 (Camta1) Regulates miR-212/miR-132 Expression and Insulin Secretion. Mollet IG, et al. J Biol Chem, 2016 Aug 26. PMID 27402838, Free PMC Article
  2. Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage. Muller-Borer B, et al. PLoS One, 2012. PMID 22715383, Free PMC Article
  3. Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor. Long C, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049392, Free PMC Article
  4. MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells. Kang K, et al. J Biol Chem, 2013 Aug 30. PMID 23853098, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC114278

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calmodulin-binding transcription activator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195559.1 → NP_001182488.1  calmodulin-binding transcription activator 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC106025, JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6G9L6, A6IUF2
    Related
    ENSRNOP00000083898.1, ENSRNOT00000092887.3
    Conserved Domains (6) summary
    smart01076
    Location:67 → 183
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    cd00204
    Location:1075 → 1193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01833
    Location:881 → 960
    TIG; IPT/TIG domain
    pfam10243
    Location:1210 → 1496
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam13637
    Location:1122 → 1173
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1074 → 1117
    ANK; ANK repeat [structural motif]

  2. NM_001195560.1 → NP_001182489.1  calmodulin-binding transcription activator 1 isoform 2

    See identical proteins and their annotated locations for NP_001182489.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate, 3' terminal exon compared to variant 1. This results in a much shorter protein (isoform 2) that lacks the ankyrin repeats and calmodulin-binding motifs, compared to isoform 1.
    Source sequence(s)
    BC106025, BF290446, BF290447
    UniProtKB/TrEMBL
    Q3KQW8
    Related
    ENSRNOP00000063320.3, ENSRNOT00000067481.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    166791639..167639502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288086.1 → XP_063144156.1  calmodulin-binding transcription activator 1 isoform X2

  2. XM_063288088.1 → XP_063144158.1  calmodulin-binding transcription activator 1 isoform X6

  3. XM_039110445.2 → XP_038966373.1  calmodulin-binding transcription activator 1 isoform X5

    UniProtKB/TrEMBL
    A6IUF2
    Conserved Domains (4) summary
    smart01076
    Location:67 → 183
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    sd00045
    Location:1074 → 1117
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:881 → 960
    TIG; IPT/TIG domain
    pfam12796
    Location:1079 → 1171
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_039110444.2 → XP_038966372.1  calmodulin-binding transcription activator 1 isoform X4

    UniProtKB/TrEMBL
    A6IUF2
    Related
    ENSRNOP00000103181.1, ENSRNOT00000171771.1
    Conserved Domains (4) summary
    smart01076
    Location:67 → 183
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    sd00045
    Location:1074 → 1117
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:881 → 960
    TIG; IPT/TIG domain
    pfam12796
    Location:1079 → 1171
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_039110438.2 → XP_038966366.1  calmodulin-binding transcription activator 1 isoform X3

    UniProtKB/TrEMBL
    A6IUF2
    Conserved Domains (4) summary
    smart01076
    Location:67 → 183
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    sd00045
    Location:1074 → 1117
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:881 → 960
    TIG; IPT/TIG domain
    pfam12796
    Location:1079 → 1171
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_039110436.2 → XP_038966364.1  calmodulin-binding transcription activator 1 isoform X1

    UniProtKB/TrEMBL
    A6IUF2
    Related
    ENSRNOP00000059056.5, ENSRNOT00000066120.5
    Conserved Domains (4) summary
    smart01076
    Location:67 → 183
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    sd00045
    Location:1074 → 1117
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:881 → 960
    TIG; IPT/TIG domain
    pfam12796
    Location:1079 → 1171
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_063288090.1 → XP_063144160.1  calmodulin-binding transcription activator 1 isoform X8

    UniProtKB/TrEMBL
    F1M4M6

  8. XM_063288089.1 → XP_063144159.1  calmodulin-binding transcription activator 1 isoform X7

  9. XM_063288092.1 → XP_063144162.1  calmodulin-binding transcription activator 1 isoform X10

  10. XM_063288091.1 → XP_063144161.1  calmodulin-binding transcription activator 1 isoform X9

RNA

  1. XR_010066428.1 RNA Sequence

  2. XR_010066435.1 RNA Sequence

  3. XR_010066434.1 RNA Sequence

  4. XR_010066427.1 RNA Sequence

  5. XR_010066426.1 RNA Sequence

  6. XR_010066429.1 RNA Sequence

  7. XR_010066430.1 RNA Sequence

  8. XR_010066432.1 RNA Sequence

  9. XR_010066431.1 RNA Sequence

  10. XR_010066433.1 RNA Sequence

  11. XR_010066436.1 RNA Sequence

  12. XR_010066439.1 RNA Sequence

  13. XR_010066440.1 RNA Sequence

  14. XR_010066437.1 RNA Sequence

  15. XR_010066438.1 RNA Sequence

  16. XR_005504502.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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