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Usp48 ubiquitin specific peptidase 48 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362636, updated on 2-Nov-2024

Summary

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Symbol
Usp48provided by RGD
Full Name
ubiquitin specific peptidase 48provided by RGD
Primary source
RGD:735213
See related
EnsemblRapid:ENSRNOG00000013602 AllianceGenome:RGD:735213
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Usp31; synUSP
Summary
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Located in postsynaptic membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human USP48 (ubiquitin specific peptidase 48). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 195.1), Spleen (RPKM 146.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Usp48 in Genome Data Viewer
Location:
5q36
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (155083520..155151208)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (149800189..149867838)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (155935102..156002722)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 2 Neighboring gene interferon induced transmembrane protein 2, pseudogene 3 Neighboring gene Rap1 GTPase-activating protein Neighboring gene alkaline phosphatase, biomineralization associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel ubiquitin-specific protease, synUSP, is localized at the post-synaptic density and post-synaptic lipid raft. Tian QB, et al. J Neurochem, 2003 Nov. PMID 14535949
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 48
Names
deubiquitinating enzyme 48
synaptic ubiquitin-specific protease
ubiquitin carboxyl-terminal hydrolase 48-like
ubiquitin specific protease 31
ubiquitin specific protease 48
ubiquitin thioesterase 48
ubiquitin thiolesterase 48
ubiquitin-specific-processing protease 48
NP_942080.2
XP_006239296.1
XP_006239297.1
XP_006239298.1
XP_006239299.1
XP_038966349.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198785.2 → NP_942080.2  ubiquitin carboxyl-terminal hydrolase 48

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q76LT8
    Related
    ENSRNOP00000030008.6, ENSRNOT00000031855.7
    Conserved Domains (3) summary
    cd02668
    Location:90 → 419
    Peptidase_C19L; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd01795
    Location:940 → 1035
    Ubl_USP48; ubiquitin-like (Ubl) domain found in ubiquitin-specific-processing protease 48 (USP48) and similar proteins
    pfam06337
    Location:484 → 554
    DUSP; DUSP domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    155083520..155151208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239234.5 → XP_006239296.1  ubiquitin carboxyl-terminal hydrolase 48 isoform X1

    UniProtKB/Swiss-Prot
    Q76LT8
    UniProtKB/TrEMBL
    A0A0G2JUQ8
    Conserved Domains (4) summary
    cd01795
    Location:958 → 1064
    USP48_C; USP ubiquitin-specific protease
    cd02668
    Location:118 → 447
    Peptidase_C19L; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:117 → 446
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam06337
    Location:512 → 582
    DUSP; DUSP domain

  2. XM_006239235.5 → XP_006239297.1  ubiquitin carboxyl-terminal hydrolase 48 isoform X2

    UniProtKB/Swiss-Prot
    Q76LT8
    Conserved Domains (4) summary
    cd01795
    Location:957 → 1063
    USP48_C; USP ubiquitin-specific protease
    cd02668
    Location:118 → 447
    Peptidase_C19L; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:117 → 446
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam06337
    Location:512 → 582
    DUSP; DUSP domain

  3. XM_006239236.5 → XP_006239298.1  ubiquitin carboxyl-terminal hydrolase 48 isoform X3

    UniProtKB/Swiss-Prot
    Q76LT8
    Conserved Domains (4) summary
    cd01795
    Location:957 → 1063
    USP48_C; USP ubiquitin-specific protease
    cd02668
    Location:118 → 446
    Peptidase_C19L; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:117 → 445
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam06337
    Location:511 → 581
    DUSP; DUSP domain

  4. XM_006239237.5 → XP_006239299.1  ubiquitin carboxyl-terminal hydrolase 48 isoform X4

    UniProtKB/Swiss-Prot
    Q76LT8
    Related
    ENSRNOP00000069188.3, ENSRNOT00000077933.3
    Conserved Domains (4) summary
    cd01795
    Location:956 → 1062
    USP48_C; USP ubiquitin-specific protease
    cd02668
    Location:118 → 446
    Peptidase_C19L; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:117 → 445
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam06337
    Location:511 → 581
    DUSP; DUSP domain

  5. XM_039110421.2 → XP_038966349.1  ubiquitin carboxyl-terminal hydrolase 48 isoform X5

    Conserved Domains (1) summary
    cd02668
    Location:118 → 447
    Peptidase_C19L; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

RNA

  1. XR_592739.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q76LT8.1 GenPept UniProtKB/Swiss-Prot:Q76LT8

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