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Adhfe1 alcohol dehydrogenase, iron containing, 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362474, updated on 28-Oct-2024

Summary

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Official Symbol
Adhfe1provided by RGD
Official Full Name
alcohol dehydrogenase, iron containing, 1provided by RGD
Primary source
RGD:1308863
See related
EnsemblRapid:ENSRNOG00000007069 AllianceGenome:RGD:1308863
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable alcohol dehydrogenase (NAD+) activity and hydroxyacid-oxoacid transhydrogenase activity. Predicted to be involved in glutamate catabolic process via 2-hydroxyglutarate. Predicted to be active in mitochondrion. Orthologous to human ADHFE1 (alcohol dehydrogenase iron containing 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Kidney (RPKM 430.7), Liver (RPKM 332.8) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adhfe1 in Genome Data Viewer
Location:
5q11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (14488784..14515405, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9705966..9732580, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (9403194..9429783, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene MYB proto-oncogene like 1 Neighboring gene vexin Neighboring gene ribosome biogenesis regulator 1 homolog Neighboring gene syntrophin, gamma 1 Neighboring gene transformer 2 alpha, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differentiation-dependent expression of Adhfe1 in adipogenesis. Kim JY, et al. Arch Biochem Biophys, 2007 Aug 1. PMID 17559793, Free PMC Article
  2. Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias. Struys EA, et al. J Inherit Metab Dis, 2005. PMID 16435184
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alcohol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alcohol dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxyacid-oxoacid transhydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxyacid-oxoacid transhydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydroxyacid-oxoacid transhydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in glutamate catabolic process via 2-hydroxyglutarate IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamate catabolic process via 2-hydroxyglutarate ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamate catabolic process via 2-hydroxyglutarate ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
hydroxyacid-oxoacid transhydrogenase, mitochondrial
Names
HOT
alcohol dehydrogenase iron-containing protein 1
NP_001020594.1
XP_038966130.1
XP_038966131.1
XP_038966133.1
XP_038966134.1
XP_038966136.1
XP_038966137.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025423.1 → NP_001020594.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial

    See identical proteins and their annotated locations for NP_001020594.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097945
    UniProtKB/Swiss-Prot
    Q4QQW3
    UniProtKB/TrEMBL
    A0A8L2Q4Z6, A6JFG4
    Related
    ENSRNOP00000106825.1, ENSRNOT00000123710.1
    Conserved Domains (1) summary
    cd08190
    Location:51 → 464
    HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    14488784..14515405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110206.2 → XP_038966134.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X3

    Conserved Domains (1) summary
    cd08190
    Location:32 → 377
    HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

  2. XM_039110208.2 → XP_038966136.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X4

    Conserved Domains (1) summary
    cd08190
    Location:23 → 368
    HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

  3. XM_039110203.2 → XP_038966131.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q4Z6, A6JFG6
    Related
    ENSRNOP00000009462.6, ENSRNOT00000009462.8
    Conserved Domains (1) summary
    cd08190
    Location:3 → 416
    HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

  4. XM_039110209.2 → XP_038966137.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X4

    Conserved Domains (1) summary
    cd08190
    Location:23 → 368
    HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

  5. XM_039110205.2 → XP_038966133.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X2

    Conserved Domains (1) summary
    cd08190
    Location:44 → 389
    HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

  6. XM_039110202.2 → XP_038966130.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q4Z6, A6JFG6
    Conserved Domains (1) summary
    cd08190
    Location:3 → 416
    HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4QQW3.1 GenPept UniProtKB/Swiss-Prot:Q4QQW3

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