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Clec2g C-type lectin domain family 2, member G [ Rattus norvegicus (Norway rat) ]

Gene ID: 362447, updated on 17-Aug-2024

Summary

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Official Symbol
Clec2gprovided by RGD
Official Full Name
C-type lectin domain family 2, member Gprovided by RGD
Primary source
RGD:1563148
See related
EnsemblRapid:ENSRNOG00000059538 AllianceGenome:RGD:1563148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Clrb; Clr-b; Clr11; CLEC2D11; RGD1563148
Summary
Predicted to enable natural killer cell lectin-like receptor binding activity. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC2D (C-type lectin domain family 2 member D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 4381.3), Spleen (RPKM 2908.6) and 8 other tissues See more
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Genomic context

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See Clec2g in Genome Data Viewer
Location:
4q42
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (164303865..164313737)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (162617827..162627699)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (162934195..162942891)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene Rhox homeobox family member 5, pseudogene 1 Neighboring gene uncharacterized LOC100909928 Neighboring gene Cd69 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Clr-b missing-self axis. Voigt S, et al. Immunity, 2007 May. PMID 17462921
  2. Two major groups of rat NKR-P1 receptors can be distinguished based on chromosomal localization, phylogenetic analysis and Clr ligand binding. Kveberg L, et al. Eur J Immunol, 2009 Feb. PMID 19130483
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. existence of lectin-like genes in several poxviruses suggests that this may represent a common theme for viral evasion of innate immunity
    Title: Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Clr-b missing-self axis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables natural killer cell lectin-like receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C-type lectin domain family 2 member D11
Names
C-type lectin domain family 2, member d11
C-type lectin-related protein 11
C-type lectin-related protein B
Ocil/Clrb-like protein
lectin-like transmembrane protein
osteoclast inhibitory lectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048075.2 → NP_001041540.1  C-type lectin domain family 2 member D11

    See identical proteins and their annotated locations for NP_001041540.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q0H8B7, Q0H8B8, Q0H8B9
    UniProtKB/TrEMBL
    B8PS70
    Related
    ENSRNOP00000069630.3, ENSRNOT00000083188.3
    Conserved Domains (2) summary
    cd03593
    Location:80 → 192
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    PHA02867
    Location:41 → 196
    PHA02867; C-type lectin protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    164303865..164313737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107902.1 → XP_038963830.1  C-type lectin domain family 2 member D11 isoform X1

    UniProtKB/TrEMBL
    A6IM36
    Conserved Domains (1) summary
    PHA02642
    Location:14 → 160
    PHA02642; C-type lectin-like protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0H8B9.1 GenPept UniProtKB/Swiss-Prot:Q0H8B9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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