U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362300, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Agap3provided by RGD
Official Full Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3provided by RGD
Primary source
RGD:1310751
See related
EnsemblRapid:ENSRNOG00000012764 AllianceGenome:RGD:1310751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Centg3
Summary
Predicted to enable GTPase activator activity; GTPase activity; and polyubiquitin modification-dependent protein binding activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Brain (RPKM 71.5), Lung (RPKM 55.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Agap3 in Genome Data Viewer
Location:
4q11
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (11567191..11617610, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10674746..10724848, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7202330..7253386, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 10 Neighboring gene gastrulation brain homeobox 1 Neighboring gene uncharacterized LOC134486542 Neighboring gene transmembrane and ubiquitin-like domain containing 1 Neighboring gene Fas-activated serine/threonine kinase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study. Højgaard K, et al. Mol Brain, 2023 Sep 25. PMID 37749596, Free PMC Article
  2. AGAP3 and Arf6 regulate trafficking of AMPA receptors and synaptic plasticity. Oku Y, et al. J Neurosci, 2013 Jul 31. PMID 23904596, Free PMC Article
  3. A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein. Qin Q, et al. J Cell Biol, 2006 Feb 13. PMID 16461359, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study.
    Title: Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
Names
centaurin, gamma 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398853.1 → NP_001385782.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    Related
    ENSRNOP00000070947.3, ENSRNOT00000087120.3
    Conserved Domains (5) summary
    cd04103
    Location:127 → 284
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd01250
    Location:400 → 542
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:686 → 716
    ANK; ANK repeat [structural motif]
    cd08855
    Location:558 → 667
    ArfGap_AGAP3; ArfGAP with GTPase domain, ANK repeat and PH domain 3
    pfam12796
    Location:686 → 776
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    11567191..11617610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235941.5 → XP_006236003.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K2D4, U6A022
    Related
    ENSRNOP00000072199.2, ENSRNOT00000084777.3
    Conserved Domains (8) summary
    cd04103
    Location:127 → 284
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    smart00010
    Location:125 → 290
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd00204
    Location:787 → 876
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:400 → 643
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00169
    Location:403 → 464
    PH; PH domain
    pfam01412
    Location:671 → 776
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:787 → 877
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:787 → 817
    ANK; ANK repeat [structural motif]

  2. XM_008762650.4 → XP_008760872.2  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X12

    UniProtKB/TrEMBL
    U6A022

  3. XM_006235938.5 → XP_006236000.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1

    Conserved Domains (8) summary
    cd04103
    Location:311 → 468
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    smart00010
    Location:309 → 474
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd00204
    Location:971 → 1060
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:584 → 827
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00169
    Location:587 → 648
    PH; PH domain
    pfam01412
    Location:855 → 960
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:971 → 1061
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:971 → 1001
    ANK; ANK repeat [structural motif]

  4. XM_006235940.5 → XP_006236002.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y9H3
    Conserved Domains (8) summary
    cd04103
    Location:311 → 468
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    smart00010
    Location:309 → 474
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd00204
    Location:870 → 959
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:584 → 726
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00169
    Location:587 → 721
    PH; PH domain
    pfam01412
    Location:754 → 859
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:870 → 960
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:870 → 900
    ANK; ANK repeat [structural motif]

  5. XM_006235939.5 → XP_006236001.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X2

    Conserved Domains (8) summary
    cd04103
    Location:311 → 468
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    smart00010
    Location:309 → 474
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd00204
    Location:925 → 1014
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:584 → 781
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00169
    Location:587 → 648
    PH; PH domain
    pfam01412
    Location:809 → 914
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:925 → 1015
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:925 → 955
    ANK; ANK repeat [structural motif]

  6. XM_039107750.2 → XP_038963678.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X10

    UniProtKB/TrEMBL
    A6K545
    Conserved Domains (4) summary
    cd01250
    Location:55 → 197
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:341 → 371
    ANK; ANK repeat [structural motif]
    cd08855
    Location:213 → 322
    ArfGap_AGAP3; ArfGAP with GTPase domain, ANK repeat and PH domain 3
    pfam12796
    Location:341 → 431
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_039107748.2 → XP_038963676.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X8

    UniProtKB/TrEMBL
    A6K545
    Conserved Domains (5) summary
    PHA03247
    Location:122 → 252
    PHA03247; large tegument protein UL36; Provisional
    cd01250
    Location:55 → 298
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:442 → 472
    ANK; ANK repeat [structural motif]
    cl28907
    Location:314 → 423
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    pfam12796
    Location:442 → 532
    Ank_2; Ankyrin repeats (3 copies)

  8. XM_039107749.2 → XP_038963677.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X9

    UniProtKB/TrEMBL
    A6K545
    Conserved Domains (4) summary
    sd00045
    Location:344 → 374
    ANK; ANK repeat [structural motif]
    cl28907
    Location:216 → 325
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    pfam12796
    Location:344 → 434
    Ank_2; Ankyrin repeats (3 copies)
    cl17171
    Location:1 → 200
    PH-like; Pleckstrin homology-like domain

  9. XM_063286226.1 → XP_063142296.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X5

  10. XM_006235943.5 → XP_006236005.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X11

    UniProtKB/TrEMBL
    A0A0G2JZ83
    Related
    ENSRNOP00000100965.1, ENSRNOT00000171340.1
    Conserved Domains (2) summary
    cd04103
    Location:127 → 284
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    smart00010
    Location:125 → 290
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

  11. XM_017592682.3 → XP_017448171.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X7

    UniProtKB/TrEMBL
    G3V9Z5
    Related
    ENSRNOP00000063846.2, ENSRNOT00000064386.4

  12. XM_063286227.1 → XP_063142297.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108616.1: Suppressed sequence

    Description
    NM_001108616.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools