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Srsf6 serine and arginine rich splicing factor 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362264, updated on 28-Oct-2024

Summary

Official Symbol
Srsf6provided by RGD
Official Full Name
serine and arginine rich splicing factor 6provided by RGD
Primary source
RGD:1359241
See related
EnsemblRapid:ENSRNOG00000006380 AllianceGenome:RGD:1359241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sfrs6
Summary
Predicted to enable mRNA binding activity and pre-mRNA binding activity. Involved in negative regulation of gene expression; negative regulation of type B pancreatic cell apoptotic process; and response to insulin. Predicted to be located in nuclear speck. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in proliferative diabetic retinopathy and spermatogenic failure 3. Orthologous to human SRSF6 (serine and arginine rich splicing factor 6). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Thymus (RPKM 483.7), Spleen (RPKM 416.5) and 9 other tissues See more
Orthologs
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Genomic context

See Srsf6 in Genome Data Viewer
Location:
3q42
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (172009072..172014395)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (151589546..151594869)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (159305345..159310668)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L28, pseudogene 6 Neighboring gene cytochrome c oxidase assembly factor 6, pseudogene 1 Neighboring gene L3MBTL histone methyl-lysine binding protein 1 Neighboring gene serum/glucocorticoid regulated kinase 2 Neighboring gene uncharacterized LOC120101778

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables pre-mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mRNA splice site recognition ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA splice site recognition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of keratinocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type B pancreatic cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of keratinocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
serine/arginine-rich splicing factor 6
Names
pre-mRNA-splicing factor SRP55
splicing factor, arginine/serine-rich 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014185.2NP_001014207.2  serine/arginine-rich splicing factor 6

    See identical proteins and their annotated locations for NP_001014207.2

    Status: VALIDATED

    Source sequence(s)
    FM060375, FM081417, JAXUCZ010000003
    UniProtKB/Swiss-Prot
    G3V6S8, Q5PQM1
    Related
    ENSRNOP00000008427.5, ENSRNOT00000008427.8
    Conserved Domains (2) summary
    cd12766
    Location:110182
    RRM2_SRSF6; RNA recognition motif 2 (RRM2) found found in vertebrate serine/arginine-rich splicing factor 6 (SRSF6)
    cl17169
    Location:172
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    172009072..172014395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)