C5 complement C5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C5provided by RGD
Official Full Name: complement C5provided by RGD
Primary source: RGD:2237
See related: EnsemblRapid:ENSRNOG00000018899 AllianceGenome:RGD:2237
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hc; C5a; RGD1561905
Summary: Enables C5a anaphylatoxin chemotactic receptor binding activity. Involved in several processes, including intracellular calcium ion homeostasis; leukocyte migration involved in inflammatory response; and negative regulation of catecholamine secretion. Located in extracellular space. Used to study adult respiratory distress syndrome; asthma; and neutropenia. Biomarker of brain edema. Human ortholog(s) of this gene implicated in several diseases, including complement component 5 deficiency; liver cirrhosis; neutropenia; paroxysmal nocturnal hemoglobinuria; and pneumonia. Orthologous to human C5 (complement C5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 1566.0), Kidney (RPKM 267.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 3p11

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (38668174..38759468, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (18270696..18361994, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (14206466..14229141, complement) , (14049993..14113931, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms.
Title: C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms.
Immunopathology of terminal complement activation and complement C5 blockade creating a pro-survival and organ-protective phenotype in trauma.
Title: Immunopathology of terminal complement activation and complement C5 blockade creating a pro-survival and organ-protective phenotype in trauma.
Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-kappabeta and ASK1 Pathways.
Title: Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-κβ and ASK1 Pathways.
Evidence for a pivotal role of the C5a/C5aR1 axis in propagating renal injury in the development of diabetic kidney disease (DKD) by disrupting mitochondrial agility, thereby establishing a new immunometabolic signaling pathway in DKD.
Title: Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility.
IL-1beta can increase C5a expression in RSC-364 cells, and C5a exerts a proinflammatory effect in RSC-364 cells.
Title: Inhibition of C5a prevents IL-1β-induced alternations in rat synoviocytes in vitro.
The expression of C5a was increased in synoviocytes and joint cartilage in the IM model. Proinflammatory cytokines, including TNFalpha and IL1beta were released in the activated synoviocytes via the induction of C5a, suggesting that C5a serves an important role in joint inflammatory processes.
Title: C5a aggravates dysfunction of the articular cartilage and synovial fluid in rats with knee joint immobilization.
n the complex but clinically relevant DH model the local and systemic inflammatory immune response features both, C5-dependent and C5-independent characteristics. Activation of caspase-3 in lung tissue after DH was C5-dependent whereas local inflammation in lung tissue was C5-independent.
Title: Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI).
Data indicate that absence of complement C3, complement C5 and Fc receptor subunit gamma (FcRgamma) does not impact autoantibody production in K/BxN mice.
Title: Autoantibody-mediated arthritis in the absence of C3 and activating Fcγ receptors: C5 is activated by the coagulation cascade.
Th data of this study suggested a role for the Complement C5 in malaria-induced seizures and that inhibition of the terminal complement pathway may reduce seizures and seizure-related neurocognitive deficits.
Title: Complement C5-deficient mice are protected from seizures in experimental cerebral malaria.
data indicate that the mechanism of IL-6 and TGF-beta1 production in renal tissue of Thy-1N rats is associated with sublytic C5b-9 up-regulated p300 and p300-mediated C/EBPbeta acetylation
Title: Sublytic C5b-9 induces IL-6 and TGF-β1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBPβ acetylation.

Submit: New GeneRIF Correction See all GeneRIFs (26)

General gene information

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Markers

RH143462 (e-PCR)
- UniSTS:232709

RH131515 (e-PCR)
- UniSTS:214798

D3Cebr7 (e-PCR)
- UniSTS:518983

D3Rat52 (e-PCR)
- UniSTS:118778

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C5a anaphylatoxin chemotactic receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in complement activation, alternative pathway	IEA Inferred from Electronic Annotation more info
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glomerulus development	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response to wounding	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in leukocyte migration involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dopamine secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of norepinephrine secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neutrophil homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
part_of membrane attack complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement C5

Names: anaphylatoxin; complement component 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053020.1 → NP_444179.1 complement C5 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

A0A096P6L9, P08650, Q63078

UniProtKB/TrEMBL

A0A8I5ZDN9

Related

ENSRNOP00000025534.8, ENSRNOT00000025534.9

Conserved Domains (10) summary

cd00017
Location:691 → 759

ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...

cd02896
Location:1004 → 1309

complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...

pfam00207
Location:781 → 868

A2M; Alpha-2-macroglobulin family

pfam07677
Location:1428 → 1518

A2M_recep; A-macroglobulin receptor

pfam17789
Location:359 → 462

MG4; Macroglobulin domain MG4

pfam17790
Location:25 → 125

MG1; Macroglobulin domain MG1

pfam17791
Location:226 → 310

MG3; Macroglobulin domain MG3

pfam01835
Location:131 → 224

A2M_N; MG2 domain

pfam07703
Location:475 → 615

A2M_N_2; Alpha-2-macroglobulin family N-terminal region

cl02512
Location:1536 → 1685

NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...