Ntmt1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ntmt1provided by RGD
Official Full Name: N-terminal Xaa-Pro-Lys N-methyltransferase 1provided by RGD
Primary source: RGD:1306582
See related: EnsemblRapid:ENSRNOG00000024809 AllianceGenome:RGD:1306582
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NTM1A; Mettl11a; RGD1306582
Summary: Predicted to enable N-terminal protein N-methyltransferase activity and histone methyltransferase activity. Predicted to be involved in N-terminal protein amino acid methylation; chromosome segregation; and spindle organization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 127.0), Muscle (RPKM 109.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (34490972..34508316)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (14093374..14110565)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (9642748..9659633)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH124227 (e-PCR)
- UniSTS:161049

BI277553 (e-PCR)
- UniSTS:243790

BF387456 (e-PCR)
- UniSTS:244364

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-terminal protein N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-terminal protein N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables N-terminal protein N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in N-terminal peptidyl-alanine trimethylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-glycine methylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-glycine methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-terminal peptidyl-proline dimethylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-proline dimethylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-terminal peptidyl-serine dimethylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-serine dimethylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-terminal peptidyl-serine trimethylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-serine trimethylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-terminal protein amino acid methylation	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle organization	ISO Inferred from Sequence Orthology more info
involved_in spindle organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: N-terminal Xaa-Pro-Lys N-methyltransferase 1

Names: X-Pro-Lys N-terminal protein methyltransferase 1A; alpha N-terminal protein methyltransferase 1A; methyltransferase like 11A; methyltransferase-like protein 11A

NP_001020190.1

EC 2.1.1.244

XP_006233981.1

EC 2.1.1.244

XP_008759892.1

EC 2.1.1.244

XP_017447369.1

EC 2.1.1.244

XP_038961298.1

EC 2.1.1.244

XP_038961299.1

EC 2.1.1.244

XP_038961300.1

EC 2.1.1.244

XP_038961301.1

EC 2.1.1.244

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025019.1 → NP_001020190.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1

See identical proteins and their annotated locations for NP_001020190.1

Status: PROVISIONAL

Source sequence(s)

BC091294

UniProtKB/Swiss-Prot

Q5BJX0

UniProtKB/TrEMBL

A6JU01

Conserved Domains (1) summary

pfam05891
Location:8 → 223

Methyltransf_PK; AdoMet dependent proline di-methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

34490972..34508316

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233919.5 → XP_006233981.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZZE9

Related

ENSRNOP00000085096.1, ENSRNOT00000111041.2

Conserved Domains (1) summary

pfam05891
Location:64 → 279

Methyltransf_PK; AdoMet dependent proline di-methyltransferase
XM_039105372.2 → XP_038961300.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X3

Conserved Domains (1) summary

cl17173
Location:64 → 166

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039105371.2 → XP_038961299.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X2

UniProtKB/Swiss-Prot

Q5BJX0

UniProtKB/TrEMBL

A6JU01

Conserved Domains (1) summary

pfam05891
Location:8 → 223

Methyltransf_PK; AdoMet dependent proline di-methyltransferase
XM_039105370.2 → XP_038961298.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X2

UniProtKB/Swiss-Prot

Q5BJX0

UniProtKB/TrEMBL

A6JU01

Conserved Domains (1) summary

pfam05891
Location:8 → 223

Methyltransf_PK; AdoMet dependent proline di-methyltransferase
XM_008761670.4 → XP_008759892.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X2

See identical proteins and their annotated locations for XP_008759892.1

UniProtKB/Swiss-Prot

Q5BJX0

UniProtKB/TrEMBL

A6JU01

Related

ENSRNOP00000035921.5, ENSRNOT00000035805.8

Conserved Domains (1) summary

pfam05891
Location:8 → 223

Methyltransf_PK; AdoMet dependent proline di-methyltransferase
XM_017591880.3 → XP_017447369.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X4

UniProtKB/TrEMBL

A6JU03

Conserved Domains (1) summary

cl17173
Location:1 → 135

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039105373.2 → XP_038961301.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X5

Conserved Domains (1) summary

cl17173
Location:26 → 193

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...