Ndst4 N-deacetylase and N-sulfotransferase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ndst4provided by RGD
Official Full Name: N-deacetylase and N-sulfotransferase 4provided by RGD
Primary source: RGD:1306531
See related: EnsemblRapid:ENSRNOG00000009577 AllianceGenome:RGD:1306531
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Orthologous to human NDST4 (N-deacetylase and N-sulfotransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 33.2), Uterus (RPKM 4.9) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (216461542..216794035)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (213787010..214119514)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (229170781..229496732)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetylglucosamine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables [heparan sulfate]-glucosamine N-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables [heparan sulfate]-glucosamine N-sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deacetylase activity	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparin biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

Names: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4; N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4; N-deacetylase/N-sulfotransferase 4

NP_001178778.1

EC 2.8.2.8

XP_038958644.1

EC 2.8.2.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191849.3 → NP_001178778.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

See identical proteins and their annotated locations for NP_001178778.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

D3ZD27

Related

ENSRNOP00000012773.5, ENSRNOT00000012773.7

Conserved Domains (2) summary

pfam00685
Location:594 → 845

Sulfotransfer_1; Sulfotransferase domain

pfam12062
Location:20 → 505

HSNSD; heparan sulfate-N-deacetylase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

216461542..216794035

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102716.2 → XP_038958644.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 isoform X1

UniProtKB/TrEMBL

D3ZD27

Conserved Domains (2) summary

pfam00685
Location:594 → 845

Sulfotransfer_1; Sulfotransferase domain

pfam12062
Location:20 → 505

HSNSD; heparan sulfate-N-deacetylase