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Alg14 ALG14, UDP-N-acetylglucosaminyltransferase subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 362031, updated on 2-Nov-2024

Summary

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Official Symbol
Alg14provided by RGD
Official Full Name
ALG14, UDP-N-acetylglucosaminyltransferase subunitprovided by RGD
Primary source
RGD:1312003
See related
EnsemblRapid:ENSRNOG00000011528 AllianceGenome:RGD:1312003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1312003
Summary
Predicted to enable protein-membrane adaptor activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to act upstream of with a positive effect on protein N-linked glycosylation. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Predicted to be active in cytoplasmic side of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 15. Orthologous to human ALG14 (ALG14 UDP-N-acetylglucosaminyltransferase subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 95.8), Lung (RPKM 86.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Alg14 in Genome Data Viewer
Location:
2q42
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (212053008..212130136)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (209368285..209445425)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (224851352..224931461)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene TLC domain containing 4 Neighboring gene ribosomal protein S19, pseudogene 5 Neighboring gene uncharacterized LOC120100935 Neighboring gene uncharacterized LOC103691685

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-membrane adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-membrane adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dolichol-linked oligosaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_positive_effect protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of UDP-N-acetylglucosamine transferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of UDP-N-acetylglucosamine transferase complex IEA
Inferred from Electronic Annotation
more info
  
part_of UDP-N-acetylglucosamine transferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of UDP-N-acetylglucosamine transferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic side of endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic side of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
UDP-N-acetylglucosamine transferase subunit ALG14; UDP-N-acetylglucosamine transferase subunit ALG14 homolog
Names
asparagine-linked glycosylation 14 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014176.2 → NP_001014198.1  UDP-N-acetylglucosamine transferase subunit ALG14

    See identical proteins and their annotated locations for NP_001014198.1

    Status: VALIDATED

    Source sequence(s)
    BC079151, BI292249, CO400199
    UniProtKB/Swiss-Prot
    Q6AY85
    UniProtKB/TrEMBL
    A0A8L2UIZ1, A6HVD6
    Conserved Domains (1) summary
    pfam08660
    Location:39 → 215
    Alg14; Oligosaccharide biosynthesis protein Alg14 like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    212053008..212130136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233243.5 → XP_006233305.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X3

    Conserved Domains (1) summary
    cl10013
    Location:39 → 94
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

  2. XM_017590978.3 → XP_017446467.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X3

    Conserved Domains (1) summary
    cl10013
    Location:39 → 94
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

  3. XM_008761465.3 → XP_008759687.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X1

    Conserved Domains (1) summary
    cl10013
    Location:39 → 262
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

  4. XM_039102713.2 → XP_038958641.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X4

    Conserved Domains (1) summary
    cl10013
    Location:39 → 94
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

  5. XM_039102714.2 → XP_038958642.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X5

    Conserved Domains (1) summary
    cl10013
    Location:39 → 94
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

  6. XM_008761466.4 → XP_008759688.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X2

    Related
    ENSRNOP00000015355.6, ENSRNOT00000015354.7
    Conserved Domains (1) summary
    cl10013
    Location:39 → 140
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

  7. XM_039102715.2 → XP_038958643.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X6

    Conserved Domains (1) summary
    cl10013
    Location:39 → 140
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

RNA

  1. XR_005500319.2 RNA Sequence

  2. XR_010063627.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY85.1 GenPept UniProtKB/Swiss-Prot:Q6AY85

Gene LinkOut

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