Gpr89b G protein-coupled receptor 89B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr89bprovided by RGD
Official Full Name: G protein-coupled receptor 89Bprovided by RGD
Primary source: RGD:1304837
See related: EnsemblRapid:ENSRNOG00000000095 AllianceGenome:RGD:1304837
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr89; RGD1304837
Summary: Predicted to enable voltage-gated anion channel activity. Predicted to be involved in T cell differentiation; intracellular pH reduction; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to act upstream of or within skin development. Predicted to be located in Golgi-associated vesicle membrane. Predicted to be active in Golgi cisterna membrane. Orthologous to human GPR89A (G protein-coupled receptor 89A) and GPR89B (G protein-coupled receptor 89B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 130.5), Kidney (RPKM 125.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (187096970..187134391, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (184408136..184445560, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (198999945..199038702, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables voltage-gated monoatomic anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic anion channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in intracellular pH reduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular pH reduction	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in skin development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi cisterna membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi cisterna membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi-associated vesicle membrane	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G protein-coupled receptor 89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001139486.1 → NP_001132958.1 G protein-coupled receptor 89

Status: VALIDATED

Source sequence(s)

BC166718, CO387870, DY546285, DY548897

UniProtKB/TrEMBL

A6K3A0, F1LTD0

Related

ENSRNOP00000000106.5, ENSRNOT00000000106.8

Conserved Domains (2) summary

pfam12430
Location:276 → 444

ABA_GPCR; Abscisic acid G-protein coupled receptor

pfam12537
Location:140 → 207

GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal