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Wdr41 WD repeat domain 41 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361879, updated on 2-Nov-2024

Summary

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Official Symbol
Wdr41provided by RGD
Official Full Name
WD repeat domain 41provided by RGD
Primary source
RGD:1306363
See related
EnsemblRapid:ENSRNOG00000025462 AllianceGenome:RGD:1306363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activator activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of autophagy. Predicted to be located in cytoplasm. Predicted to be part of Atg1/ULK1 kinase complex and guanyl-nucleotide exchange factor complex. Orthologous to human WDR41 (WD repeat domain 41). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 78.6), Brain (RPKM 74.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wdr41 in Genome Data Viewer
Location:
2q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (27957453..28008573)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (26222797..26273849)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (24668108..24717280)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350223 Neighboring gene orthopedia homeobox Neighboring gene phosphodiesterase 8B Neighboring gene uncharacterized LOC134485577 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway. Sullivan PM, et al. Acta Neuropathol Commun, 2016 May 18. PMID 27193190, Free PMC Article
  2. A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Yang M, et al. Sci Adv, 2016 Sep. PMID 27617292, Free PMC Article
  3. Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. Sellier C, et al. EMBO J, 2016 Jun 15. PMID 27103069, Free PMC Article
  4. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Atg1/ULK1 kinase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of guanyl-nucleotide exchange factor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395597.2 → NP_001382526.1  WD repeat-containing protein 41 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I5ZYE1, B2RYI7
    Related
    ENSRNOP00000061347.3, ENSRNOT00000067022.6
    Conserved Domains (2) summary
    sd00039
    Location:87 → 133
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:38 → 350
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001395716.1 → NP_001382645.1  WD repeat-containing protein 41 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I5ZYE1, F7ETI3
    Related
    ENSRNOP00000031387.7, ENSRNOT00000036748.7
    Conserved Domains (2) summary
    sd00039
    Location:87 → 132
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:38 → 349
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    27957453..28008573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102530.2 → XP_038958458.1  WD repeat-containing protein 41 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYE1
    Related
    ENSRNOP00000084562.2, ENSRNOT00000109022.2
    Conserved Domains (2) summary
    sd00039
    Location:76 → 122
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:27 → 339
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108541.1: Suppressed sequence

    Description
    NM_001108541.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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