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Pitpnm1 phosphatidylinositol transfer protein, membrane-associated 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361694, updated on 2-Nov-2024

Summary

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Official Symbol
Pitpnm1provided by RGD
Official Full Name
phosphatidylinositol transfer protein, membrane-associated 1provided by RGD
Primary source
RGD:1306710
See related
EnsemblRapid:ENSRNOG00000018553 AllianceGenome:RGD:1306710
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pitpnm
Summary
Predicted to enable several functions, including phospholipid binding activity; phospholipid transporter activity; and receptor tyrosine kinase binding activity. Predicted to be involved in phospholipid transport. Located in cell body. Orthologous to human PITPNM1 (phosphatidylinositol transfer protein membrane associated 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 292.7), Spleen (RPKM 111.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pitpnm1 in Genome Data Viewer
Location:
1q43
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210823568..210836989)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201394099..201407523)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219348672..219362094)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene calcium binding protein 2 Neighboring gene cyclin-dependent kinase 2 associated protein 2 Neighboring gene aryl-hydrocarbon receptor-interacting protein Neighboring gene transmembrane protein 134 Neighboring gene calcium binding protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid. Garner K, et al. J Biol Chem, 2012 Sep 14. PMID 22822086, Free PMC Article
  2. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Lev S, et al. Mol Cell Biol, 1999 Mar. PMID 10022914, Free PMC Article
  3. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC95131

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylcholine binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylcholine transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol transfer activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membrane-associated phosphatidylinositol transfer protein 1
Names
NIR-2
PITPnm 1
phosphatidylinositol membrane-associated
pyk2 N-terminal domain-interacting receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008369.1 → NP_001008370.1  membrane-associated phosphatidylinositol transfer protein 1

    See identical proteins and their annotated locations for NP_001008370.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085945
    UniProtKB/Swiss-Prot
    Q5U2N3
    UniProtKB/TrEMBL
    A6HYT2
    Related
    ENSRNOP00000025084.3, ENSRNOT00000025084.6
    Conserved Domains (3) summary
    cd08889
    Location:1 → 257
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1021 → 1152
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    pfam02862
    Location:687 → 877
    DDHD; DDHD domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    210823568..210836989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268158.1 → XP_063124228.1  membrane-associated phosphatidylinositol transfer protein 1 isoform X4

  2. XM_039083713.2 → XP_038939641.1  membrane-associated phosphatidylinositol transfer protein 1 isoform X3

    Conserved Domains (2) summary
    cd08889
    Location:1 → 278
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    pfam02862
    Location:708 → 898
    DDHD; DDHD domain

  3. XM_039083707.2 → XP_038939635.1  membrane-associated phosphatidylinositol transfer protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQF3
    Related
    ENSRNOP00000096308.1, ENSRNOT00000105000.2
    Conserved Domains (3) summary
    cd08889
    Location:1 → 278
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1042 → 1173
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    pfam02862
    Location:708 → 898
    DDHD; DDHD domain

  4. XM_063268157.1 → XP_063124227.1  membrane-associated phosphatidylinositol transfer protein 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2N3.1 GenPept UniProtKB/Swiss-Prot:Q5U2N3

Gene LinkOut

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