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Acsm5 acyl-CoA synthetase medium-chain family member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361637, updated on 28-Oct-2024

Summary

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Official Symbol
Acsm5provided by RGD
Official Full Name
acyl-CoA synthetase medium-chain family member 5provided by RGD
Primary source
RGD:1309578
See related
EnsemblRapid:ENSRNOG00000031211 AllianceGenome:RGD:1309578
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cc1-38; Aa2-174; RGD1309578
Summary
Predicted to enable fatty acid ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human ACSM5 (acyl-CoA synthetase medium chain family member 5). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Liver (RPKM 1151.3) and Lung (RPKM 64.5) See more
Orthologs
human mouse all
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Genomic context

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See Acsm5 in Genome Data Viewer
Location:
1q35
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (183302241..183328175)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (173870873..173896838)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (189240955..189270422)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glycoprotein 2 Neighboring gene uromodulin Neighboring gene protein disulfide isomerase-like, testis expressed Neighboring gene acyl-CoA synthetase medium-chain family member 2 Neighboring gene RGD1559600 Neighboring gene acyl-CoA synthetase medium-chain family member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty-acyl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables medium-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
acyl-coenzyme A synthetase ACSM5, mitochondrial
NP_001014184.3
XP_006230185.1
XP_038938781.1
XP_038938785.1
XP_038938787.1
XP_063123652.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014162.5 → NP_001014184.3  acyl-coenzyme A synthetase ACSM5, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001014184.3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q6AYT9
    Conserved Domains (1) summary
    cl17068
    Location:48 → 576
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    183302241..183328175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230123.3 → XP_006230185.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006230185.1

    UniProtKB/Swiss-Prot
    Q6AYT9
    Related
    ENSRNOP00000047613.3, ENSRNOT00000046025.6
    Conserved Domains (1) summary
    cl17068
    Location:48 → 576
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. XM_039082853.2 → XP_038938781.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6AYT9
    Conserved Domains (1) summary
    cl17068
    Location:48 → 576
    AFD_class_I; Adenylate forming domain, Class I superfamily

  3. XM_063267582.1 → XP_063123652.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X2

  4. XM_039082857.2 → XP_038938785.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl17068
    Location:1 → 436
    AFD_class_I; Adenylate forming domain, Class I superfamily

  5. XM_039082859.2 → XP_038938787.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl17068
    Location:1 → 436
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYT9.1 GenPept UniProtKB/Swiss-Prot:Q6AYT9

Gene LinkOut

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