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Zfp143 zinc finger protein 143 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361627, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp143provided by RGD
Official Full Name
zinc finger protein 143provided by RGD
Primary source
RGD:1305662
See related
EnsemblRapid:ENSRNOG00000010087 AllianceGenome:RGD:1305662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
STAF; Znf143
Summary
Enables chromatin binding activity. Involved in positive regulation of smooth muscle cell proliferation and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF143 (zinc finger protein 143). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 49.5), Spleen (RPKM 41.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp143 in Genome Data Viewer
Location:
1q33
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (173543810..173579667)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (164109041..164144902)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (174702310..174738133)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene NHP2 ribonucleoprotein, pseudogene 5 Neighboring gene importin 7 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene uncharacterized LOC134483773 Neighboring gene RNA, U6 small nuclear 1168 Neighboring gene WEE1 G2 checkpoint kinase Neighboring gene switching B-cell complex subunit SWAP70

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Adhesion-dependent Skp2 transcription requires selenocysteine tRNA gene transcription-activating factor (STAF). Hernández-Negrete I, et al. Biochem J, 2011 May 15. PMID 21352097, Free PMC Article
  2. Transcriptional regulation of the mouse cytosolic chaperonin subunit gene Ccta/t-complex polypeptide 1 by selenocysteine tRNA gene transcription activating factor family zinc finger proteins. Kubota H, et al. J Biol Chem, 2000 Sep 15. PMID 10893243
  3. Regulation of aldehyde reductase expression by STAF and CHOP. Barski OA, et al. Genomics, 2004 Jan. PMID 14667815
  4. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, et al. Cell Cycle, 2010 Sep 15. PMID 20890107, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of snRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 143
Names
selenocysteine tRNA gene transcription-activating factor
zfp-143
NP_001012169.2
XP_006230056.1
XP_038938655.1
XP_063123513.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012169.3 → NP_001012169.2  zinc finger protein 143

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q5XIU2
    UniProtKB/TrEMBL
    A0A0H2UHI0, A6I808
    Related
    ENSRNOP00000013733.9, ENSRNOT00000013733.7
    Conserved Domains (3) summary
    COG5048
    Location:251 → 424
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:207 → 292
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    173543810..173579667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229994.3 → XP_006230056.1  zinc finger protein 143 isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHI0
    Conserved Domains (3) summary
    sd00017
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:312 → 339
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:298 → 413
    zf-C2H2_8; C2H2-type zinc ribbon

  2. XM_039082727.2 → XP_038938655.1  zinc finger protein 143 isoform X2

    UniProtKB/Swiss-Prot
    Q5XIU2
    UniProtKB/TrEMBL
    A0A0H2UHI0, A6I808
    Related
    ENSRNOP00000109958.1, ENSRNOT00000140259.1
    Conserved Domains (3) summary
    COG5048
    Location:251 → 424
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:207 → 292
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_063267443.1 → XP_063123513.1  zinc finger protein 143 isoform X1

    Related
    ENSRNOP00000077653.1, ENSRNOT00000119146.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIU2.2 GenPept UniProtKB/Swiss-Prot:Q5XIU2

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