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Ppp6r1 protein phosphatase 6, regulatory subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361502, updated on 2-Nov-2024

Summary

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Official Symbol
Ppp6r1provided by RGD
Official Full Name
protein phosphatase 6, regulatory subunit 1provided by RGD
Primary source
RGD:1311409
See related
EnsemblRapid:ENSRNOG00000018090 AllianceGenome:RGD:1311409
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Saps1; RGD1311409
Summary
Predicted to enable protein phosphatase regulator activity and small GTPase binding activity. Predicted to be involved in regulation of signal transduction. Predicted to be active in cytosol and nucleus. Orthologous to human PPP6R1 (protein phosphatase 6 regulatory subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 267.8), Spleen (RPKM 219.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppp6r1 in Genome Data Viewer
Location:
1q12
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78218629..78246360)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69190856..69217598)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72756819..72784492)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene BR serine/threonine kinase 1 Neighboring gene uncharacterized LOC108349434 Neighboring gene HSPA (Hsp70) binding protein 1 Neighboring gene transmembrane protein 86B Neighboring gene protein tyrosine phosphatase, receptor type, H Neighboring gene uncharacterized LOC108349515

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Role of the Rho GTPase-activating protein RICS in neurite outgrowth. Nasu-Nishimura Y, et al. Genes Cells, 2006 Jun. PMID 16716191
  2. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. Lant B, et al. Nat Commun, 2015 Mar 6. PMID 25743393
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 6 regulatory subunit 1
Names
SAPS domain family, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135849.2 → NP_001129321.1  serine/threonine-protein phosphatase 6 regulatory subunit 1

    See identical proteins and their annotated locations for NP_001129321.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KNM6
    Related
    ENSRNOP00000101673.1, ENSRNOT00000127951.1
    Conserved Domains (2) summary
    pfam04499
    Location:128 → 519
    SAPS; SIT4 phosphatase-associated protein
    pfam06121
    Location:715 → 811
    DUF959; Domain of Unknown Function (DUF959)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    78218629..78246360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266286.1 → XP_063122356.1  serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X1

    Related
    ENSRNOP00000106703.1, ENSRNOT00000156853.1

  2. XM_063266288.1 → XP_063122358.1  serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X2

  3. XM_063266289.1 → XP_063122359.1  serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X3

    Related
    ENSRNOP00000112167.1, ENSRNOT00000082423.3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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