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Adat2 adenosine deaminase, tRNA-specific 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361453, updated on 2-Nov-2024

Summary

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Official Symbol
Adat2provided by RGD
Official Full Name
adenosine deaminase, tRNA-specific 2provided by RGD
Primary source
RGD:1309642
See related
AllianceGenome:RGD:1309642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Deadc1
Summary
Predicted to enable tRNA-specific adenosine-34 deaminase activity and zinc ion binding activity. Predicted to be involved in tRNA wobble adenosine to inosine editing. Orthologous to human ADAT2 (adenosine deaminase tRNA specific 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 71.5), Spleen (RPKM 60.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adat2 in Genome Data Viewer
Location:
1p13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (9774680..9795376)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (7954520..7975254)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (7726447..7743112)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene alpha-L-fucosidase 2 Neighboring gene peroxisomal biogenesis factor 3 Neighboring gene uncharacterized LOC120098785 Neighboring gene cofilin 1, pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tRNA-specific adenosine-34 deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA wobble adenosine to inosine editing IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA-specific adenosine deaminase 2
Names
deaminase domain containing 1
NP_001108500.1
XP_038937004.1
XP_038937010.1
XP_038937016.1
XP_063122049.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115028.3 → NP_001108500.1  tRNA-specific adenosine deaminase 2

    See identical proteins and their annotated locations for NP_001108500.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    B0BMY9
    Conserved Domains (1) summary
    COG0590
    Location:23 → 173
    TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    9774680..9795376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265979.1 → XP_063122049.1  tRNA-specific adenosine deaminase 2 isoform X2

  2. XM_039081076.2 → XP_038937004.1  tRNA-specific adenosine deaminase 2 isoform X1

    Conserved Domains (1) summary
    COG0590
    Location:23 → 161
    TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

  3. XM_039081088.2 → XP_038937016.1  tRNA-specific adenosine deaminase 2 isoform X4

    Conserved Domains (1) summary
    COG0590
    Location:4 → 114
    TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

  4. XM_039081082.2 → XP_038937010.1  tRNA-specific adenosine deaminase 2 isoform X3

    Conserved Domains (1) summary
    COG0590
    Location:4 → 126
    TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_010054015.1 RNA Sequence

  2. XR_010054014.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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